Abstract
CD8+cytotoxic T lymphocytes (TCD8+) play major roles in the acute response to intracellular pathogens and in maintaining the latent state in chronic virus infections. There is great hope that TCD8+responses can be manipulated to treat neoplasms. Major histocompatibility complex (MHC) class I molecules display endogenously processed antigenic (Ag) peptides to TCD8+. This shapes the developing TCD8+repertoire in the thymus and enables the delivery of immune effector molecules to antigen-presenting cells (APCs) in the periphery.
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Chen, W., Bennink, J.R., Yewde, J.W. (2000). Quantitating Presentation of MHC Class I-Restricted Antigens. In: Solheim, J.C. (eds) Antigen Processing and Presentation Protocols. Methods in Molecular Biology, vol 156. Humana Press. https://doi.org/10.1385/1-59259-062-4:245
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DOI: https://doi.org/10.1385/1-59259-062-4:245
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