Synthesis of Aminobenzoic Acid-Based Nonpeptide Templates
Applications in Peptidomimetic Drug Discovery
Part of the Methods in Molecular Medicine™ book series (MIMM, volume 23)
Aminobenzoic acid-based congeners are emerging as a useful class of nonpeptide templates for applications in peptidomimetic drug discovery. Exemplifying such compounds are recently described antagonists or inhibitors of several receptor and signal transduction protein targets, including, integrin gpIIbIIIa receptor antagonists (1), Ras farnesyl protein transferase inhibitors (2), Src SH2 domain antagonists (3), and growth hormone-releasing peptide (GHRP) receptor agonists (4). Representative examples of these compounds are shown in Fig. 1.
KeywordsEthyl Acetate Citric Acid Hydroxylamine Hydrochloride Saturated Aqueous Solution Generic Template
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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