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Synthesis of Aminobenzoic Acid-Based Nonpeptide Templates

Applications in Peptidomimetic Drug Discovery
  • Kimberly S. Para
  • Tomi K. Sawyer
Part of the Methods in Molecular Medicine™ book series (MIMM, volume 23)

Abstract

Aminobenzoic acid-based congeners are emerging as a useful class of nonpeptide templates for applications in peptidomimetic drug discovery. Exemplifying such compounds are recently described antagonists or inhibitors of several receptor and signal transduction protein targets, including, integrin gpIIbIIIa receptor antagonists (1), Ras farnesyl protein transferase inhibitors (2), Src SH2 domain antagonists (3), and growth hormone-releasing peptide (GHRP) receptor agonists (4). Representative examples of these compounds are shown in Fig. 1.
Fig. 1.

Chemical structures of integrin receptor antagonist, Ras famesyl protein transferase inhibitor, Src SH2 domain antagonist, and GHRP receptor agonist leads, which incorporate aminobenzoic acid-based nonpeptide templates.

Keywords

Ethyl Acetate Citric Acid Hydroxylamine Hydrochloride Saturated Aqueous Solution Generic Template 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Humana Press Inc., Totowa, NJ 1999

Authors and Affiliations

  • Kimberly S. Para
    • 1
  • Tomi K. Sawyer
    • 2
  1. 1.Parke-Davis Pharmaceutical ResearchAnn Arbor
  2. 2.Department of Organic ChemistryParke-Davis Pharmaceutical ResearchAnn Arbor

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