Synthesis of Peptidomimics Through Sugar-Based Scaffolds

  • Yves Le Merrer
  • Lydie Poitout
  • Jean-Claude Depezay
Part of the Methods in Molecular Medicine™ book series (MIMM, volume 23)


Poor oral bioavailability, low metabolic stability towards proteolysis and rapid excretion via both liver and kidneys displayed by innumerable peptides of potential therapeutic value has generated an intensive search for peptidomimics (1, 2). A possible approach of such nonpeptidal peptidomimics is to replace the peptide by a scaffold that distributes in the space the peptidal side chains of amino acids essential for biological activity and mimics the bioactive conformation of the peptide.


Aqueous Layer Anhydrous Na2SO4 Combine Organic Layer Saturated Aqueous Solution Azido Group 
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Copyright information

© Humana Press Inc., Totowa, NJ 1999

Authors and Affiliations

  • Yves Le Merrer
    • 1
  • Lydie Poitout
    • 1
  • Jean-Claude Depezay
    • 1
  1. 1.Laboratoire de Chimie et de Biochimie Pharmacologiques et ToxicologiquesUniversite Rene DescartesParisFrance

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