Abstract
Lactam-bridged dipeptides are useful tools for the introduction of conformational constraint in higher peptides. General methods have been devised for the synthesis of dipeptides having five-, six-, and seven-membered ring constraints (1,2). This chapter will focus on four synthetic paths from protected chiral a-amino acids to lactams that involve intramolecular alkylation, intermolecular alkylation, intramolecular acylation, and condensation with formaldehyde for a one carbon unit insertion.
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Ā© 1999 Humana Press Inc., Totowa, NJ
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Perlow, D.S., Freidinger, R.M. (1999). Synthesis of Protected Lactam-Bridged Dipeptides. In: Kazmierski, W.M. (eds) Peptidomimetics Protocols. Methods in Molecular Medicineā¢, vol 23. Humana Press. https://doi.org/10.1385/0-89603-517-4:209
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DOI: https://doi.org/10.1385/0-89603-517-4:209
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