Synthesis of a Versatile Peptidomimetic Scaffold

  • Stephen Hanessian
  • Grant McNaughton-Smith
Part of the Methods in Molecular Medicine™ book series (MIMM, volume 23)


The need to replace natural amino acids in peptides with nonproteinogenic counterparts in order to obtain drug-like target molecules has stimulated a great deal of innovation on several fronts (1, 2, 3). One of the more exciting areas of research in drug design has been the synthesis of so-called secondary structure peptidomimetic molecules that are expected to have the same therapeutic effects as natural peptide counterparts, with the added advantage of metabolic stability (4,5). Of particular interest to us has been the replacement of a dipeptide motif in a given natural substrate with a constrained or rigidified counterpart that stimulates β-turn formation (6,7). In particular, we have been investigating the generation of a general synthetic pathway towards a variety of substituted peptidomimetic core structures. Various appendages could then be attached to these central core units either by standard iterative conditions or, more preferably, by using combinatorial techniques. This chapter will describe the preparation of one such novel peptidomimetic nucleus and its elaboration to a fully extended β-turn peptidomimetic.


Combine Organic Boron Trifluoride Etherate Ethylcarbodiimide Hydrochloride Saturated Aqueous NaHCO3 Tetrabutylammonium Iodide 
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Copyright information

© Humana Press Inc., Totowa, NJ 1999

Authors and Affiliations

  • Stephen Hanessian
    • 1
  • Grant McNaughton-Smith
    • 1
  1. 1.Department de ChimieUniversite de MontrealMontrealQuebecCanada

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