Abstract
Dopamine receptors are members of a large family of neurotransmitter/hormone receptors that exert their biological actions via signal transduction pathways that involve subtype-specific guanine nucleotide binding or G proteins (see Kaziro et al., 1991; Simon et al., 1991; Hille, 1992; Iyengar, 1993; Clapham and Neer, 1993; Gilman, 1995; Rodbell, 1995; Raymond, 1995). On the basis of biochemical, pharmacological and physiological criteria, receptors for dopamine within the central nervous system and periphery have been classified into two types, termed Dl and D2 (see reviews: Kebabian and Calne, 1979; Seeman, 1980; Niznik, 1987; Niznik and Jarvie 1989; Niznik and Van Tol, 1992; Kebabian, 1993; Hall, 1994; Lokhandwala and Chen, 1994). Operationally, native membrane-bound dopamine Dl receptors are defined by their ability to stimulate, via Gs or Golf (Herve et al., 1993), adenylate cyclase activity which subsequently activates cAMP-dependent protein kinases (see Hemmings et al., 1987; Lovenberg et al., 1991; Niznik et al, 1992).
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Pristupa, Z.B., Sunahara, R.K., Niznik, H.B. (1997). G Protein α- and βγ-Subunits as Possible Mediators of Dopamine-D1:D2 Receptor Ligand Binding Interactions. In: Mishra, R.K., Baker, G.B., Boulton, A.A. (eds) G Protein Methods and Protocols. Neuromethods, vol 31. Humana Press. https://doi.org/10.1385/0-89603-490-9:81
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