Abstract
Protein prenylation involves the covalent attachment of Cl5 farnesyl or C20 geranylgeranyl (GG) isoprenoids to cysteine resrdues located at or near the COOH-terminus of various proteins. The majority of cellular proteins that are known to undergo this modtfrcation are small guanosme triphosphate phosphohydrolases (GTPases) belonging to the Ras, Rho/Rat, and Rab families. Each of these proteins require one or more COOH-terminal prenyl groups for proper subcellular localization and function (1).
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Seabra, M.C., James, G.L. (1998). Prenylation Assays for Small GTPases. In: Bar-Sagi, D. (eds) Transmembrane Signaling Protocols. Methods In Molecular Biology™, vol 84. Humana Press. https://doi.org/10.1385/0-89603-488-7:251
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DOI: https://doi.org/10.1385/0-89603-488-7:251
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