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Methods for Gene Transfer to Synovium

  • Richard Kang
  • Paul D. Robbins
  • Christopher H. Evans
Part of the Methods in Molecular Medicine book series (MIMM, volume 7)

Abstract

Development of methods for gene transfer to synoviocytes was borne from the idea that gene therapy could be used to more effectively treat rheumatoid arthritis (EU) and other joint disorders (1). Current pharmaceutical modalities in use against RA have limited effectiveness because of problems related to inefficient targeting of drugs to the joint, as well as inefficacies of the drugs themselves. Drug delivery to the joint by traditional oral, iv, and intramuscular routes, depends on passive diffusion of the drug from the synovial vasculature into the joint space (2). Thus, high systemic concentrations of the drug are necessary to achieve therapeutic intra-articular drug levels; in chronic RA, perfusion of the synovium may be compromised (3), driving required systemic drug levels even higher. This is of major concern, as the pharmaceuticals used to treat this disease are associated with serious side effects. Further compounding these problems is the chronic nature of RA, which requires lifelong treatment with high dosages of these drugs.

Keywords

Joint Space Synovial Tissue Patellar Tendon Medial Collateral Ligament Synovial Fibroblast 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Humana Press Inc., Totowa, NJ 1997

Authors and Affiliations

  • Richard Kang
    • 1
  • Paul D. Robbins
    • 2
  • Christopher H. Evans
    • 3
  1. 1.Orthopedic SurgeryUniversity of Pittsburgh School of MedicinePittsburgh
  2. 2.Department of Molecular Genetics and BiochemistryUniversity of Pittsburgh
  3. 3.Department of Molecular Genetics and BiochemistryUniversity of Pittsburgh Medical CenterPittsburgh

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