Abstract
The introduction of pseudopeptide bonds (amide bond surrogates) into the peptide backbone during synthesis is now a common technique in peptide chemistry (1). These pseudo-peptide bonds are introduced in order to satisfy criteria such as stability to enzymatic degradation, transition state analogs/enzyme inhibition, alteration in peptide backbone conformation (with corresponding changes in flexibility and hydrogen-bonding character), increased receptor specificity, increased potency, and biological responses (2).
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© 1997 Humana Press Inc. Totowa, NJ
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Anderson, G.J. (1997). Incorporation of Stable Pseudopeptide Bonds. In: Irvine, G.B., Williams, C.H. (eds) Neuropeptide Protocols. Methods in Molecular Biology™, vol 73. Humana Press. https://doi.org/10.1385/0-89603-399-6:49
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DOI: https://doi.org/10.1385/0-89603-399-6:49
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