Abstract
This chapter describes methods for the successful two-dimensional modeling of a small catalytic RNA. Our laboratory has used these methods to model and name the hairpin ribozyme family based on secondary structure predicted from computer modeling and mutagenesis (see Chapter 19) (1,2,3). The methodology has two basic components: postulation and testing of the model.
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References
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© 1997 Humana Press Inc.
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Siwkowski, A., DeYoung, M.B., Anderson, P., Hampel, A. (1997). Mutagenesis and Modeling of the Hairpin Ribozyme Family. In: Turner, P.C. (eds) Ribozyme Protocols. Methods in Molecular Biology™, vol 74. Humana Press. https://doi.org/10.1385/0-89603-389-9:357
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DOI: https://doi.org/10.1385/0-89603-389-9:357
Publisher Name: Humana Press
Print ISBN: 978-0-89603-389-4
Online ISBN: 978-1-59259-560-0
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