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PrP-Deficient Mice in the Study of Transmissible Spongiform Encephalopathies

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Prion Diseases

Part of the book series: Methods in Molecular Medicine ((MIMM,volume 3))

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Abstract

The Transmissible Spongiform Encephalopathies (TSEs), such as scrapre, BSE, and Creutzfeldt-Jakob disease, are associated with alterations in the neural membrane protein or prion protein (PrP). This chapter will outline the gene targeting approaches that have been used to mutate the murine PrP gene, resulting in mice with reduction or absence of the PrP protein. It will then describe how these transgenuic animals can contribute to our understanding of the role of PrP in agent replication, the pathology of the TSEs, and the normal function of PrP

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Author information

Authors and Affiliations

  1. BBSRC/MRC Neuropathogenesis Unit, Institute for Animal Health, Edinburgh, UK

    Jean C. Manson

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  1. Jean C. Manson
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Editor information

Editors and Affiliations

  1. Cambridge University, Cambridge, UK

    Harry F. Baker  & Rosalind M. Ridley  & 

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© 1996 Humana Press Inc., Totowa, NJ

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Manson, J.C. (1996). PrP-Deficient Mice in the Study of Transmissible Spongiform Encephalopathies. In: Baker, H.F., Ridley, R.M. (eds) Prion Diseases. Methods in Molecular Medicine, vol 3. Springer, Totowa, NJ. https://doi.org/10.1385/0-89603-342-2:237

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  • DOI: https://doi.org/10.1385/0-89603-342-2:237

  • Publisher Name: Springer, Totowa, NJ

  • Print ISBN: 978-0-89603-342-9

  • Online ISBN: 978-1-59259-587-7

  • eBook Packages: Springer Protocols

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