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The Characterization of Chromosomal Abnormalities Using Fluorescence In SituHybridization Procedures

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Molecular Diagnosis of Cancer

Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 6))

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Cytogenetic changes are important in understanding the pathogenesis of disease. Karyotypic analysis is particularly useful when investigatmg conditions such as human malignancies, where aneuploidy and structural chromosome rearrangements are commonly found, as in the human leukemias. In these, karyotypes can show a wide range of different structural rearrangements, with highly specific chromosome abnormalities that are used in the classification of leukemras (1), which, in turn, are related to specific clinical features.

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Authors and Affiliations

  1. Department of Molecular Haematology, Institute of Child Health, LRF Centre for Childhood Leukaemia, London, UK

    Helena M. Kempski

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  1. Helena M. Kempski
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Editors and Affiliations

  1. University London, UK

    Finbarr E. Cotter

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© 1996 Humana Press Inc., Totowa, NJ

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Kempski, H.M. (1996). The Characterization of Chromosomal Abnormalities Using Fluorescence In SituHybridization Procedures. In: Cotter, F.E. (eds) Molecular Diagnosis of Cancer. Methods in Molecular Medicine™, vol 6. Humana Press. https://doi.org/10.1385/0-89603-341-4:161

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  • DOI: https://doi.org/10.1385/0-89603-341-4:161

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-341-2

  • Online ISBN: 978-1-59259-590-7

  • eBook Packages: Springer Protocols

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