Antisense Tumor Therapy

Activated C-Ha-ras Oncogene in the Mouse
  • Eric Wickstrom
Part of the Methods in Molecular Medicine book series (MIMM, volume 1)


Cancerous cells display overexpression or mutant expression of one or more of the genes normally used in cell proliferation. Such genes are called protoncogenes (1). The imphcation is that the targets that must be attacked in neoplastic cells are normal cellular genes that have sustained some activating lesion. The ras family of mammalian proto-oncogenes includes three members, termed Ha-ras, Ki-ras, and N-ras, that are found to be activated very often in human solid tumors and leukemias (2).


NIH3T3 Cell Focus Formation Antisense Inhibition Rabbit Reticulocyte Lysate mRNA Secondary Structure 
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Copyright information

© Humana Press Inc., Totowa, NJ 1996

Authors and Affiliations

  • Eric Wickstrom
    • 1
  1. 1.Department of PharmacologyThomas Jefferson UniversityPhiladelphia

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