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Chromosome Analysis Protocols pp 141–185Cite as

Automatic Karyotype Analysis

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Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 29))

Abstract

This chapter differs from the majority in this book in that its subject matter is the application of computer image interpretation techniques to the analysis of metaphase chromosome spreads. Were we to follow the prescription of the remainder of the book, we might simply publish the code of a computer program together with a list of suitable equipment. This is not, however, a realistic option. The computer programs in current commercial systems for automated cytogenetics typically consist of approximately 100,000 lines of source code; in the case of automatic metaphase finders, the equipment may include proprietary mechanical or electronic components. Also, the rate of change in the performance and cost of cameras, displays, and computers are such that any list of equipment that is appropriate as we write in mid1991 would most likely be nearing obsolescence by the time the book is published.

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Author information

Authors and Affiliations

  1. Wolfson Image Analysis Unit, Department of Medical Biophysics, University of Manchester, Manchester, UK

    Jim Graham

  2. Medical Research Council, Human Genetics Unit, Western General Hospital, Edinburgh, UK

    Jim Piper

Authors
  1. Jim Graham
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  2. Jim Piper
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Editor information

Editors and Affiliations

  1. Medical Research Council, Edinburgh, Scotland

    John R. Gosden

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© 1994 Humana Press Inc, Totowa, NJ

About this protocol

Cite this protocol

Graham, J., Piper, J. (1994). Automatic Karyotype Analysis. In: Gosden, J.R. (eds) Chromosome Analysis Protocols. Methods in Molecular Biology™, vol 29. Humana Press. https://doi.org/10.1385/0-89603-289-2:141

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  • DOI: https://doi.org/10.1385/0-89603-289-2:141

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-289-7

  • Online ISBN: 978-1-59259-516-7

  • eBook Packages: Springer Protocols

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