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Behavioral Techniques for Assessing Drug Tolerance and Sensitization

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Book cover Psychopharmacology

Part of the book series: Neuromethods ((NM,volume 13))

Abstract

The term tolerance typically refers to the relatively common observation that during chronic drug treatment the effect(s) of some drugs may progressively reduce in magnitude. For example, there is now evidence suggesting that in a variety of animal models of anxiety, the anxiety-reducing actions of the widely prescribed benzodiazepine drugs show tolerance during long-term treatment (Vellucci and File, 1979 117; Treit, 1985 116; Stephens and Schneider, 1985 108). In contrast to tolerance, the term sensitization refers to the observation that during chronic treatment some drug effects actually increase in magnitude. For example, it is well established that sensitization develops to the motoric effects of psychostimulant drugs (Kilbey and Sannerud, 1985 69) and to the therapeutic effects of antidepressants

“The more one extends the experimentation on a given tolerance phenomenon, the more one finds evidence for the existence of multiple mechanisms” (Bignami et al., 1975 10)

“We must expect that more than one mechanism will be involved in the development of tolerance to a drug, even in a single individual at a particular time” (Dews, 1978 34).

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Author information

Authors and Affiliations

  1. Department of Psychology, Liverpool University, Liverpool, England

    Andrew J. Goudie

Authors
  1. Andrew J. Goudie
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Editor information

Editors and Affiliations

  1. Neuropsychiatric Research Unit, University of Saskatchewan, Saskatoon, Canada

    Alan A. Boulton

  2. Neurochemical Research Unit, University of Alberta, Edmonton, Canada

    Glen B. Baker  & Andrew J. Greenshaw  & 

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© 1989 The Humana Press Inc.

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Goudie, A.J. (1989). Behavioral Techniques for Assessing Drug Tolerance and Sensitization. In: Boulton, A.A., Baker, G.B., Greenshaw, A.J. (eds) Psychopharmacology. Neuromethods, vol 13. Humana Press, Totowa, NJ. https://doi.org/10.1385/0-89603-129-2:565

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  • DOI: https://doi.org/10.1385/0-89603-129-2:565

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-0-89603-129-6

  • Online ISBN: 978-1-59259-618-8

  • eBook Packages: Springer Protocols

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