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Cerebrovascular Water and Ion Transport

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The Neuronal Microenvironment

Part of the book series: Neuromethods ((NM,volume 9))

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Abstract

The capillaries of the central nervous system (CNS) are unique among the blood vessels of the body in having tight junctions between adjacent endothelial cells, no fenestrae, and a complete pericapillary investment (the glial foot processes) between parenchymal cells and capillary endothelium. The net result of these singular properties is to transform an ordinary capillary endothelium into a formidable restriction to the passage of both solute and solvent, a blood-brain barrier (BBB). The BBB serves to passively isolate the brain interstitial microenvironment from the plasma and, by means of carrier transport systems resident on the capillary endothelial wall, to actively regulate the passage of substrates and metabolites between the blood and the brain extracellular space. Taken together, these active and passive regulatory functions of the BBB serve to maintain an optimal environment for neuronal function and for transfer of information within the brain parenchyma (Nicholson, 1980; Cserr and Bundgaard, 1984).

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Authors and Affiliations

  1. Department of Medicine, Division of Pulmonary and Critical Care Medicine, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey

    Joseph E. Melton

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  1. Joseph E. Melton
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Editors and Affiliations

  1. University of Saskatchewan, Saskatchewan, Canada

    Alan A. Boulton  & Wolfgang Walz  & 

  2. University of Alberta, Alberta, Canada

    Glen B. Baker

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Melton, J.E. (1988). Cerebrovascular Water and Ion Transport. In: Boulton, A.A., Baker, G.B., Walz, W. (eds) The Neuronal Microenvironment. Neuromethods, vol 9. Humana Press. https://doi.org/10.1385/0-89603-115-2:1

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  • DOI: https://doi.org/10.1385/0-89603-115-2:1

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-115-9

  • Online ISBN: 978-1-59259-614-0

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