Wnt Signaling as a Therapeutic Target for Cancer

  • Andreas Herbst
  • Frank Thomas Kolligs
Part of the Methods in Molecular Biology™ book series (MIMB, volume 361)

Abstract

The Wnt/β-catenin signaling pathway is tightly regulated and has important functions in development, tissue homeostasis, and regeneration. Deregulation of Wnt/β-catenin signaling is frequently found in various human cancers. Eighty percent of colorectal cancers alone reveal activation of this pathway by either inactivation of the tumor-suppressor gene adenomatous polyposis coli or mutation of the proto-oncogene β-catenin. Activation of Wnt/β-catenin signaling has been found to be important for both initiation and progression of cancers of different tissues. Therefore, targeted inhibition of Wnt/β-catenin signaling is a rational and promising new approach for the therapy of cancers of various origins.

Key Words

Wnt signalling adenomatous polyposis coli APC β-catenin Tcf LEF targeted therapy small molecules antisense siRNA RNAi 

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Copyright information

© Humana Press Inc. 2007

Authors and Affiliations

  • Andreas Herbst
    • 1
    • 2
  • Frank Thomas Kolligs
    • 1
    • 2
  1. 1.Clinical Research Unit for Gastrointestinal CancersLudwig-Maximilians-UniversityMunichGermany
  2. 2.Department of Medicine II, Klinikum GrosshadernLudwig-Maximilians-UniversityMunichGermany

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