Congenital Heart Disease pp 157-169

Part of the Methods in Molecular Medicine book series (MIMM, volume 126)

“Chip”ping Away at Heart Failure

  • J. David Barrans
  • Choong-Chin Liew

Abstract

Studies in the field of microarray technology have exploded onto the scene to delve into the unknown underlying mechanisms and pathways in molecular disease. Diseases of the cardio-vascular system, particularly those with unexplained molecular etiologies, such as heart failure, have more recently been investigated using array technology. Our laboratory has sought to examine gene expression profiles of human heart failure using a 10,000+ element cardio-vascular-based complementary DNA microarray constructed in-house, termed the “CardioChip.” Our studies have identified panels of genes, such as those encoding sarcomeric and cytoskeletal proteins, stress proteins, and Ca2+ regulators, that are differentially expressed in disease conditions as compared with samples from nonfailing hearts. Microarrays are effective tools for examining molecular portraits of the cardiovascular disease condition.

Key Words

Microarray heart failure cardiomyopathy genomics cardiovascular disease 

Copyright information

© Humana Press Inc. 2006

Authors and Affiliations

  • J. David Barrans
    • 1
  • Choong-Chin Liew
    • 1
  1. 1.Department of MedicineBrigham and Women’s HospitalBoston

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