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Plasmonics-Based Nanostructures for Surface-Enhanced Raman Scattering Bioanalysis

  • Tuan Vo-Dinh
  • Fei Yan
  • David L. Stokes
Part of the Methods in Molecular Biology™ book series (MIMB, volume 300)

Summary

Surface-enhanced Raman scattering (SERS) spectroscopy is a plasmonics-based spectroscopic technique that combines modern laser spectroscopy with unique optical properties of metallic nanostructures, resulting in strongly increased Raman signals when molecules are adsorbed on or near nanometer-size structures of special metals such as gold, silver, and transition metals. This chapter provides a synopsis of the development and application of SERS-active metallic nanostructures, especially for the analysis of biologically relevant compounds. Some highlights of this chapter include reports of SERS as an immunoassay readout method, SERS gene nanoprobes, near-field scanning optical microscopy SERS probes, SERS as a tool for single-molecule detection, and SERS nanoprobes for cellular studies.

Key Words

Surface-enhanced Raman scattering genomics single-molecule detection near-field scanning optical microscopy plasmonics bioanalysis 

Notes

Acknowledgments

This work was jointly sponsored by the Federal Bureau of Investigation (Project No. 2051-II18-Y1), and the Office of Biological and Environmental Research, U.S. Department of Energy, under contract DE-AC05-00OR22725 with UT-Battelle, LLC; and by the Laboratory Directed Research and Development Program (Advanced Plasmonics Sensors Project) at Oak Ridge National Laboratory. Fei Yan and David L. Stokes are also supported by an appointment to the Oak Ridge National Laboratory Postdoctoral Research Associates Program, administered jointly by the Oak Ridge National Laboratory and Oak Ridge Institute for Science and Education.

References

  1. 1.
    Fleischmann, M., Hendra, P. J., and McQuillan, A. J. (1974) Raman-spectra of pyridine adsorbed at a silver electrode. Chem. Phys. Lett. 26, 163–166.Google Scholar
  2. 2.
    Jeanmaire, D. L. and Van Duyne, R. P. (1977) Surface Raman spectro-electrochemistry. 1. Heterocyclic, aromatic, and aliphatic-amines adsorbed on anodized silver electrode. J. Electroanal. Chem. 84, 1–20.Google Scholar
  3. 3.
    Albrecht, M. G. and Creighton, J. A. (1977) Anomalously intense Raman-spectra of pyridine at a silver electrode. J. Am. Chem. Soc. 99, 5215–5217.Google Scholar
  4. 4.
    Nie, S. M. and Emory, S. R. (1997) Probing single molecules and single nanoparticles by surface-enhanced Raman scattering. Science 275, 1102–1106.PubMedGoogle Scholar
  5. 5.
    Kneipp, K., Wang, Y., Kneipp, H., Perelman, L. T., Itzkan, I., Dasari, R., and Feld, M. S. (1997) Single molecule detection using surface-enhanced Raman scattering (SERS). Phys. Rev. Lett. 78, 1667–1670.Google Scholar
  6. 6.
    Kneipp, K., Kneipp, H., Deinum, G., Itzkan, I., Dasari, R. R., and Feld, M. S. (1998) Single-molecule detection of a cyanine dye in silver colloidal solution using near-infrared surface-enhanced Raman scattering. Appl. Spectrosc. 52, 175–178.Google Scholar
  7. 7.
    Kneipp, K., Kneipp, H., Manoharan, R., Hanlon, E. B., Itzkan, I., Dasari, R. R., and Feld, M. S. (1998) Extremely large enhancement factors in surface-enhanced Raman scattering for molecules on colloidal gold clusters. Appl. Spectrosc. 52, 1493–1497.Google Scholar
  8. 8.
    Deckert, V., Zeisel, D., Zenobi, R., and Vo-Dinh, T. (1998) Near-field surface enhanced Raman imaging of dye-labeled DNA with 100-nm resolution. Anal. Chem. 70, 2646–2650.PubMedGoogle Scholar
  9. 9.
    Zeisel, D., Deckert, V., Zenobi, R., and Vo-Dinh, T. (1998) Near-field surface-enhanced Raman spectroscopy of dye molecules adsorbed on silver island films. Chem. Phys. Lett. 283, 381–385.Google Scholar
  10. 10.
    Moskovits, M. (1985) Surface-enhanced spectroscopy. Rev. Mod. Phys. 57, 783–826.Google Scholar
  11. 11.
    Wokaun, A. (1984) Surface-enhanced electromagnetic processes. Solid State Phys. Adv. Res. Applic. 38, 223–294.Google Scholar
  12. 12.
    Schatz, G. C. (1984) Theoretical-studies of surface enhanced Raman-scattering. Acc. Chem. Res. 17, 370–376.Google Scholar
  13. 13.
    Kerker, M. (1984) Electromagnetic model for surface-enhanced Raman-scattering (Sers) on metal colloids. Acc. Chem. Res. 17, 271–277.Google Scholar
  14. 14.
    Chang, R. K. and Furtak, T. E. (1982) Surface Enhanced Raman Scattering, Plenum, New York.Google Scholar
  15. 15.
    Garrell, R. L. (1989) Surface-enhanced Raman-spectroscopy. Anal. Chem. 61, 401A–411A.Google Scholar
  16. 16.
    Vo-Dinh, T. (1989) Surface-enhanced Raman spectrometry, in Chemical Analysis of Polycyclic Aromatic Compounds (Vo-Dinh, T., ed.), Wiley, New York, pp. 451–482.Google Scholar
  17. 17.
    Pemberton, J. E. (1991) in Electrochemical interfaces: modern techniques for in-situ characterization (Abruna, H. D., ed.), VCH Publishers, Inc.: New York, pp. 195–256.Google Scholar
  18. 18.
    Brandt, E. S. and Cotton, T. M. (1993) Surface-enhanced Raman scattering. In Investigations of Surfaces and Interfaces Part B, Physical Methods of Chemistry Series, 2nd ed., Rossiter, B. W., (Baetzold, R. C., eds.), Wiley, New York, pp. 663–718.Google Scholar
  19. 19.
    Otto, A., Mrozek, I., Grabhorn, H., and Akemann, W. (1992) Surface-enhanced Raman-scattering. J. Phys. Condensed Matter 4, 1143–1212.Google Scholar
  20. 20.
    Vo-Dinh, T. (1995) Surface-enhanced Raman spectroscopy, in Photonic Probes of Surfaces (Halevi, P., ed.), Elsevier, New York, pp. 65–96.Google Scholar
  21. 21.
    Ruperez, A. and Laserna, J. J. (1996) Surface-enhanced Raman spectroscopy, in Modern Techniques in Raman Spectroscopy (Laserna, J. J., ed.), Wiley, New York, pp. 227–264.Google Scholar
  22. 22.
    Haller, K. L., Bumm, L. A., Altkorn, R. I., Zeman, E. J., Schatz, G. C., and Vanduyne, R. P. (1989) Spatially resolved surface enhanced 2nd harmonic-generation-theoretical and experimental-evidence for electromagnetic enhancement in the near-infrared on a laser microfabricated Pt surface. J. Chem. Phys. 90, 1237–1252.Google Scholar
  23. 23.
    Golab, J. T., Sprague, J. R., Carron, K. T., Schatz, G. C., and Van Duyne, R. P. (1988) A surface enhanced hyper-Raman scattering study of pyridine adsorbed onto silver—experiment and theory. J. Chem. Phys. 88, 7942–7951.Google Scholar
  24. 24.
    Vo-Dinh, T., Stokes, D. L., Griffin, G. D., Volkan, M., Kim, U. J., and Simon, M. I. (1999) Surface-enhanced Raman scattering (SERS) method and instrumentation for genomics and biomedical analysis. J. Raman Spectrosc. 30, 785–793.Google Scholar
  25. 25.
    Nabiev, I. and Manfait, M. (1993) Industrial applications of the surface-enhanced Raman-spectroscopy. Rev. Inst. Francais Petrole 48, 261–285.Google Scholar
  26. 26.
    Nabiev, I., Chourpa, I., and Manfait, M. (1994) Applications of Raman and surface-enhanced Raman-scattering spectroscopy in medicine. J. Raman Spectrosc. 25, 13–23.Google Scholar
  27. 27.
    Kneipp, K., Kneipp, H., Itzkan, I., Dasari, R. R., and Feld, M. S. (1999) Surface-enhanced Raman scattering: a new tool for biomedical spectroscopy. Curr. Sci. 77, 915–924.Google Scholar
  28. 28.
    Koglin, E. and Sequaris J. M. (1986) Surface enhanced Raman-scattering of biomolecules. Top. Curr. Chem. 134, 1–57.Google Scholar
  29. 29.
    Pemberton, J. E. and Buck, R. P. (1981) Detection of low concentrations of a colored adsorbate at silver by surface-enhanced and resonance-enhanced Raman spectrometry. Anal. Chem. 53, 2263–2267.Google Scholar
  30. 30.
    Pettinger, B., Wenning, U., and Wetzel, H. (1980) Surface-plasmon enhanced Raman-scattering frequency and angular resonance of Raman scattered-light from pyridine on Au, Ag and Cu electrodes. Surf. Sci. 101, 409–416.Google Scholar
  31. 31.
    Loo, B. H. (1983) Surface-enhanced Raman-spectroscopy of platinum. 2. Enhanced light-scattering of chlorine adsorbed on platinum. J. Phys. Chem. 87, 3003–3007.Google Scholar
  32. 32.
    Fleischmann, M., Graves, P. R., and Robinson, J. (1985) The Raman-spectroscopy of the ferricyanide ferrocyanide system at gold, beta-palladium hydride and platinum-electrodes. J. Electroanal. Chem. 182, 87–98.Google Scholar
  33. 33.
    Carrabba, M. M., Edmonds, R. B., and Rauh, R. D. (1987) Feasibility studies for the detection of organic-surface and subsurface water contaminants by surface-enhanced Raman-spectroscopy on silver electrodes. Anal. Chem. 59, 2559–2563.PubMedGoogle Scholar
  34. 34.
    Ren, B., Lin, X. F., Yang, Z. L., Liu, G. K., Aroca, R. F., Mao, B. W., and Tian, Z. Q. (2003) Surface-enhanced Raman scattering in the ultraviolet spectral region: UV-SERS on rhodium and ruthenium electrodes. J. Am. Chem. Soc. 125, 9598, 9599.PubMedGoogle Scholar
  35. 35.
    Yang, Z. L., Wu, D. Y., Yao, J. L., Hu, J. Q., Ren, B., Zhou, H. G., and Tian, Z. Q. (2002) SERS mechanism of nickel electrode. Chin. Sci. Bull. 47, 1983–1986.Google Scholar
  36. 36.
    Tian, Z. Q., Ren, B., and Wu, D. Y. (2002) Surface-enhanced Raman scattering: from noble to transition metals and from rough surfaces to ordered nanostructures. J. Phys. Chem. B 106, 9463–9483.Google Scholar
  37. 37.
    Thierry, D. and Leygraf, C. (1985) The influence of photoalteration on surface-enhanced Raman-scattering from copper electrodes. Surf. Sci. 149, 592–600.Google Scholar
  38. 38.
    Creighton, J. A., Blatchford, C. B., and Albrecht, M. C. (1979) Plasma resonance enhancement of Raman-scattering by pyridine adsorbed on silver or gold sol particles of size comparable to the excitation wavelength. J. Chem. Soc. Faraday Trans. 2, 790–798.Google Scholar
  39. 39.
    Sheng, R. S., Zhu, L., and Morris, M. D. (1986) Sedimentation classification of silver colloids for surface-enhanced Raman-scattering. Anal. Chem. 58, 1116–1119.Google Scholar
  40. 40.
    Ni, F., Sheng, R. S., and Cotton, T. M. (1990) Flow-injection analysis and real-time detection of RNA bases by surface-enhanced Raman-spectroscopy. Anal. Chem. 62, 1958–1963.PubMedGoogle Scholar
  41. 41.
    Lee, P. C. and Meisel, D. (1982) Adsorption and surface-enhanced Raman of dyes on silver and gold sols. J. Phys. Chem. 86, 3391–3395.Google Scholar
  42. 42.
    Munro, C. H., Smith, W. E., Garner, M., Clarkson, J., and White, P. C. (1995) Characterization of the surface of a citrate-reduced colloid optimized for use as a substrate for surface-enhanced resonance Raman-scattering. Langmuir 11, 3712–3720.Google Scholar
  43. 43.
    Tarabara, V. V., Nabiev, I. R., and Feofanov, A. V. (1998) Surface-enhanced Raman scattering (SERS) study of mercaptoethanol monolayer assemblies on silver citrate hydrosol: preparation and characterization of modified hydrosol as a SERS-active substrate. Langmuir 14, 1092–1098.Google Scholar
  44. 44.
    Li, Y. S., Cheng, J. C., and Coons, L. B. (1999) A silver solution for surface-enhanced Raman scattering. Spectrochim. Acta Part A 55, 1197–1207.Google Scholar
  45. 45.
    Ahern, A. M. and Garrell, R. L. (1987) In situ photoreduced silver-nitrate as a substrate for surface-enhanced Raman-spectroscopy. Anal. Chem. 59, 2813–2816.Google Scholar
  46. 46.
    Prochazka, M., Mojzes, P., Stepanek, J., Vlckova, B., and Turpin, P. Y. (1997) Probing applications of laser ablated Ag colloids in SERS spectroscopy: improvement of ablation procedure and SERS spectral testing. Anal. Chem. 69, 5103–5108.Google Scholar
  47. 47.
    Hildebrandt, P. and Stockburger, M. (1984) Surface-enhanced resonance Raman-spectroscopy of rhodamine-6G adsorbed on colloidal silver. J. Phys. Chem. 88, 5935–5944.Google Scholar
  48. 48.
    Cao, Y. W., Jin, R., and Mirkin, C. A. (2001) DNA-modified core-shell Ag/Au nanoparticles. J. Am. Chem. Soc. 123, 7961, 7962.PubMedGoogle Scholar
  49. 49.
    Pham, T., Jackson, J. B., Halas, N. J., and Lee, T. R. (2002) Preparation and characterization of gold nanoshells coated with self-assembled monolayers. Langmuir 18, 4915–4920.Google Scholar
  50. 50.
    Graf, C. and van Blaaderen, A. (2002) Metallodielectric colloidal core-shell particles for photonic applications. Langmuir 18, 524–534.Google Scholar
  51. 51.
    Jackson, J. B., Westcott, S. L., Hirsch, L. R., West, J. L., and Halas, N. J. (2003) Controlling the surface enhanced Raman effect via the nanoshell geometry. Appl. Phys. Lett. 82, 257–259.Google Scholar
  52. 52.
    Van Duyne, R. P., Hulteen, J. C., and Treichel, D. A. (1993) Atomic-force microscopy and surface-enhanced Raman-spectroscopy. 1. Ag island films and Ag film over polymer nanosphere surfaces supported on glass. J. Chem. Phys. 99, 2101–2115.Google Scholar
  53. 53.
    Semin, D. J. and Rowlen, K. L. (1994) Influence of vapor-deposition parameters on SERS active Ag film morphology and optical-properties. Anal. Chem. 66, 4324–4331.Google Scholar
  54. 54.
    Stockle, R. M., Deckert, V., Fokas, C., Zeisel, D., and Zenobi, R. (2000) Sub-wavelength Raman spectroscopy on isolated silver islands. Vibrational Spectrosc. 22, 39–48.Google Scholar
  55. 55.
    Roark, S. E. and Rowlen, K. L. (1994) Thin Ag Films—influence of substrate and postdeposition treatment on morphology and optical-properties. Anal. Chem. 66, 261–270.Google Scholar
  56. 56.
    Roark, S. E., Semin, D. J., Lo, A., Skodje, R. T., and Rowlen, K. L. (1995) Solvent-induced morphology changes in thin silver films. Anal. Chim. Acta 307, 341–353.Google Scholar
  57. 57.
    Mosier-Boss, P. A. and Lieberman, S. H. (1999) Comparison of three methods to improve adherence of thin gold films to glass substrates and their effect on the SERS response. Appl. Spectrosc. 53, 862–873.Google Scholar
  58. 58.
    Vo-Dinh, T., Hiromoto, M. Y. K., Begun, G. M., and Moody, R. L. (1984) Surface-enhanced Raman spectrometry for trace organic-analysis. Anal. Chem. 56, 1667–1670.Google Scholar
  59. 59.
    Goudonnet, J. P., Begun, G. M., and Arakawa, E. T. (1982) Surface-enhanced Raman-scattering on silver-coated Teflon sphere substrates. Chem. Phys. Lett. 92, 197–201.Google Scholar
  60. 60.
    Alak, A. M. and Vo-Dinh, T. (1989) Silver-coated fumed silica as a substrate material for surface-enhanced Raman-scattering. Anal. Chem. 61, 656–660.Google Scholar
  61. 61.
    Moody, R. L., Vo-Dinh, T., and Fletcher, W. H. (1987) Investigation of experimental parameters for surface-enhanced Raman-scattering (SERS) using silver-coated microsphere substrates. Appl. Spectrosc. 41, 966–970.Google Scholar
  62. 62.
    Alak, A. M. and Vo-Dinh, T. (1988) Surface-enhanced Raman spectrometry of chlorinated pesticides. Anal. Chim. Acta 206, 333–337.Google Scholar
  63. 63.
    Bello, J. M., Stokes, D. L., and Vo-Dinh, T. (1989) Silver-coated alumina as a new medium for surface-enhanced Raman-scattering analysis. Appl. Spectrosc. 43, 1325–1330.Google Scholar
  64. 64.
    Bello, J. M., Stokes, D. L., and Vo-Dinh, T. (1989) Titanium-dioxide based substrate for optical monitors in surface-enhanced Raman-scattering analysis. Anal. Chem. 61, 1779–1783.Google Scholar
  65. 65.
    Alak, A. M. and Vo-Dinh, T. (1987) Surface-enhanced Raman-spectrometry of organophosphorus chemical-agents. Anal. Chem. 59, 2149–2153.PubMedGoogle Scholar
  66. 66.
    Li, Y. S., Vo-Dinh, T., Stokes, D. L., and Yu, W. (1992) Surface-enhanced Raman analysis of p-nitroaniline on vacuum evaporation and chemically deposited silver-coated alumina substrates. Appl. Spectrosc. 46, 1354–1357.Google Scholar
  67. 67.
    Li, Y. S. and Wang, Y. (1992) Chemically prepared silver alumina substrate for surface-enhanced Raman-scattering. Appl. Spectrosc. 46, 142–146.Google Scholar
  68. 68.
    Helmenstine, A. M., Li, Y. S., and Vo-Dinh, T. (1993) Surface-enhanced Raman-scattering analysis of etheno adducts of adenine. Vibrational Spectrosc. 4, 359–364.Google Scholar
  69. 69.
    Helmenstine, A., Uziel, M., and Vo-Dinh, T. (1993) Measurement of DNA-adducts using surface-enhanced Raman-spectroscopy. J. Toxicol. Environ. Health 40, 195–202.PubMedGoogle Scholar
  70. 70.
    Vo-Dinh, T. and Stokes, D. L. (1993) Surface-enhanced Raman vapor dosimeter. Appl. Spectrosc. 47, 1728–1732.Google Scholar
  71. 71.
    Alarie, J. P., Stokes, D. L., Sutherland, W. S., Edwards, A. C., and Vo-Dinh, T. (1992) Intensified charge coupled device-based fiberoptic monitor for rapid remote surface-enhanced Raman-scattering sensing. Appl. Spectrosc. 46, 1608–1612.Google Scholar
  72. 72.
    Narayanan, V. A., Begun, G. M., Bello, J. M., Stokes, D. L., and Vo-Dinh, T. (1993) Analysis of the plant-growth regulator Alar (Daminozide) and its hydrolysis products using Raman-spectroscopy. Analysis 21, 107–112.Google Scholar
  73. 73.
    Narayanan, V. A., Begun, G. M., Stump, N. A., Stokes, D. L., and Vo-Dinh, T. (1993) Vibrational-spectra of fluvalinate. J. Raman Spectrosc. 24, 123–128.Google Scholar
  74. 74.
    Narayanan, V. A., Stokes, D. L., and Vo-Dinh, T. (1994) Vibrational spectral-analysis of eosin-y and erythrosin-b—intensity studies for quantitative detection of the dyes. J. Raman Spectrosc. 25, 415–422.Google Scholar
  75. 75.
    Vo-Dinh, T., Houck, K., and Stokes, D. L. (1994) Surface-enhanced Raman gene probes. Anal. Chem. 66, 3379–3383.PubMedGoogle Scholar
  76. 76.
    Vo-Dinh, T., Miller, G. H., Bello, J., Johnson, R., Moody, R. L., Alak, A., and Fletcher, W. R. (1989) Surface-active substrates for Raman and luminescence analysis. Talanta 36, 227–234.PubMedGoogle Scholar
  77. 77.
    Wachter, E. A., Storey, J. M. E., Sharp, S. L., Carron, K. T., and Jiang, Y. (1995) Hybrid substrates for real-time sers-based chemical sensors. Appl. Spectrosc. 49, 193–199.Google Scholar
  78. 78.
    Liao, P. F. (1982) in Surface Enhanced Raman Scattering (Chang, R. K. and Furtak, T. E., eds.), Plenum, New York, p. 379–390.Google Scholar
  79. 79.
    Vo-Dinh, T., Hiromoto, M. Y. K., Begun, G. M., and Moody, R. L. (1984) Surface-enhanced Raman spectrometry for trace organic-analysis. Anal. Chem. 56, 1667–1670.Google Scholar
  80. 80.
    Meier, M., Wokaun, A., and Vo-Dinh, T. (1985) Silver particles on stochastic quartz substrates providing tenfold increase in Raman enhancement. J. Phys. Chem. 89, 1843–1846.Google Scholar
  81. 81.
    Vo-Dinh, T., Meier, M., and Wokaun, A. (1986) Surface-enhanced Raman-spectrometry with silver particles on stochastic-post substrates. Anal. Chim. Acta 181, 139–148.Google Scholar
  82. 82.
    Liao, P. F. and Stern, M. B. (1982) Surface-enhanced Raman-scattering on gold and aluminum particle arrays. Opt. Lett. 7, 483–485.PubMedGoogle Scholar
  83. 83.
    Enlow, P. D., Buncick, M., Warmack, R. J., and Vo-Dinh, T. (1986) Detection of nitro polynuclear aromatic-compounds by surface-enhanced raman-spectrometry. Anal. Chem. 58, 1119–1123.Google Scholar
  84. 84.
    Volkan, M., Stokes, D. L., and Vo-Dinh, T. (1999) A new surface-enhanced Raman scattering substrate based on silver nanoparticles in sol-gel. J. Raman Spectrosc. 30, 1057–1065.Google Scholar
  85. 85.
    Volkan, M., Stokes, D. L., and Vo-Dinh, T. (2000) Surface-enhanced Raman of dopamine and neurotransmitters using sol-gel substrates and polymer-coated fiber-optic probes. Appl. Spectrosc. 54, 1842–1848.Google Scholar
  86. 86.
    Pal, A., Stokes, D. L., Alarie, J. P., and Vo-Dinh, T. (1995) Selective surface-enhanced Raman-spectroscopy using a polymer-coated substrate. Anal. Chem. 67, 3154–3159.Google Scholar
  87. 87.
    Vo-Dinh, T. and Stokes, D. L. (1999) Surface-enhanced Raman detection of chemical vapors with the use of personal dosimeters. Field Anal. Chem. Technol. 3, 346–356.Google Scholar
  88. 88.
    Stokes, D. L., Pal, A., Narayanan, V. A., and Vo-Dinh, T. (1999) Evaluation of a chemical vapor dosimeter using polymer-coated SERS substrates. Anal. Chim. Acta 399, 265–274.Google Scholar
  89. 89.
    Carron, K. T., Lewis, M. L., Dong, J. A., Ding, J. F., Xue, G., and Chen, Y. (1993) Surface-enhanced Raman-scattering and cyclic voltammetry studies of synergetic effects in the corrosion inhibition of copper by polybenzimidazole and mercaptobenzimidazole at high temperature. J. Mater. Sci. 28, 4099–4103.Google Scholar
  90. 90.
    Deschaines, T. O. and Carron, K. T. (1997) Stability and surface uniformity of selected thiol-coated SERS surfaces. Appl. Spectrosc. 51, 1355–1359.Google Scholar
  91. 91.
    Crane, L. G., Wang, D. X., Sears, L. M., Heyns, B., and Carron, K. (1995) SERS surfaces modified with a 4-(2-pyridylazo)resorcinol disulfide derivative—detection of copper, lead, and cadmium. Anal. Chem. 67, 360–364.Google Scholar
  92. 92.
    Sulk, R., Chan, C., Guicheteau, J., Gomez, C., Heyns, J. B. B., Corcoran, R., and Carron, K. (1999) Surface-enhanced Raman assays (SERA): measurement of bilirubin and salicylate. J. Raman Spectrosc. 30, 853–859.Google Scholar
  93. 93.
    Sulk, R. A., Corcoran, R. C., and Carron, K. T. (1999) Surface enhanced Raman scattering detection of amphetamine and methamphetamine by modification with 2-mercaptonicotinic acid. Appl. Spectrosc. 53, 954–959.Google Scholar
  94. 94.
    Zou, S. Z. and Weaver, M. J. (1998) Surface-enhanced Raman scattering an uniform transition metal films: toward a versatile adsorbate vibrational strategy for solid-nonvacuum interfaces? Anal. Chem. 70, 2387–2395.PubMedGoogle Scholar
  95. 95.
    Wilke, T., Gao, X. P., Takoudis, C. G., and Weaver, M. J. (1991) Surface-enhanced Raman-spectroscopy as a probe of adsorption at transition metal-high-pressure gas interfaces—NO, CO, and oxygen on platinum-coated gold, rhodium-coated gold, and ruthenium-coated gold. Langmuir 7, 714–721.Google Scholar
  96. 96.
    Tarcha, P. J., DeSaja-Gonzalez, J., Rodriguez-Llorente, S., and Aroca, R. (1999) Surface-enhanced fluorescence on SiO2-coated silver island films. Appl. Spectrosc. 53, 43–48.Google Scholar
  97. 97.
    Lacy, W. B., Olson, L. G., and Harris, J. M. (1999) Quantitative SERS measurements on dielectric-overcoated silver-island films by solution deposition control of surface concentrations. Anal. Chem. 71, 2564–2570.PubMedGoogle Scholar
  98. 98.
    Lacy, W. B., Williams, J. M., Wenzler, L. A., Beebe, T. P., and Harris, J. M. (1996) Characterization of SiO2-overcoated silver-island films as substrates for surface-enhanced Raman scattering. Anal. Chem. 68, 1003–1011.Google Scholar
  99. 99.
    Fu, X. Y., Mu, T., Wang, J., Zhu, T., and Liu, Z. F. (1998) pH-dependent assembling of gold nanoparticles on p-aminothiophenol modified gold substrate. Acta Phys.-Chim. Sinica 14, 968–974.Google Scholar
  100. 100.
    Zhu, T., Zhang, X., Wang, J., Fu, X. Y., and Liu, Z. F. (1998) Assembling colloidal Au nanoparticles with functionalized self-assembled monolayers. Thin Solid Films 329, 595–598.Google Scholar
  101. 101.
    He, H. X., Zhang, H., Li, Q. G., Zhu, T., Li, S. F. Y., and Liu, Z. F. (2000) Fabrication of designed architectures of Au nanoparticles on solid substrate with printed self-assembled monolayers as templates. Langmuir 16, 3846–3851.Google Scholar
  102. 102.
    Wang, K. and Li, Y. S. (1997) Silver doping of polycarbonate films for surface-enhanced Raman scattering. Vibrational Spectrosc. 14, 183–188.Google Scholar
  103. 103.
    Yang, X. M., Tryk, D. A., Ajito, K., Hashimoto, K., and Fujishima, A. (1996) Surface-enhanced Raman scattering imaging of photopatterned self-assembled monolayers. Langmuir 12, 5525–5527.Google Scholar
  104. 104.
    Zhu, T., Yu, H. Z., Wang, J., Wang, Y. Q., Cai, S. M., and Liu, Z. F. (1997) Two-dimensional surface enhanced Raman mapping of differently prepared gold substrates with an azobenzene self-assembled monolayer. Chem. Phys. Lett. 265, 334–340.Google Scholar
  105. 105.
    Maeda, Y., Yamamoto, H., and Kitano, H. (1995) Self-assembled monolayers as novel biomembrane mimetics. 1. Characterization of cytochrome-c bound to self-assembled monolayers on silver by surface-enhanced resonance Raman-spectroscopy. J. Phys. Chem. 99, 4837–4841.Google Scholar
  106. 106.
    Vo-Dinh, T., Allain, L. R., and Stokes, D. L. (2002) Cancer gene detection using surface-enhanced Raman scattering (SERS). J. Raman Spectrosc. 33, 511–516.Google Scholar
  107. 107.
    Michota, A., Kudelski, A., and Bukowska, J. (2000) Chemisorption of cysteamine on silver studied by surface-enhanced Raman scattering. Langmuir 16, 10,236–10,242.Google Scholar
  108. 108.
    Michota, A., Kudelski, A., and Bukowska, J. (2001) Influence of electrolytes on the structure of cysteamine monolayer on silver studied by surface-enhanced Raman scattering. J. Raman Spectrosc. 32, 345–350.Google Scholar
  109. 109.
    Culha, M., Stokes, D., Allain, L. R., and Vo-Dinh, T. (2003) Surface-enhanced Raman scattering substrate based on a self-assembled monolayer for use in gene diagnostics. Anal. Chem. 75, 6196–6201.PubMedGoogle Scholar
  110. 110.
    Culha, M., Stokes, D, and Vo-Dinh, T (2003) Surface-enhanced Raman scattering for cancer diagnostics: detection of the BCL2 gene. Expert Rev. Mol. Diagn. 3, 669–675.PubMedGoogle Scholar
  111. 111.
    Vo-Dinh, T., Stokes, D. L., Griffin, G. D., Volkan, M., Kim, U. J., and Simon, M. I. (1999) Surface-enhanced Raman scattering (SERS) method and instrumentation for genomics and biomedical analysis. J. Raman Spectrosc. 30, 785–793.Google Scholar
  112. 112.
    Isola, N. R., Stokes, D. L., and Vo-Dinh, T. (1998) Surface enhanced Raman gene probe for HIV detection. Anal. Chem. 70, 1352–1356.PubMedGoogle Scholar
  113. 113.
    Graham, D., Smith, W. E., Linacre, A. M. T., Munro, C. H., Watson, N. D., and White, P. C. (1997) Selective detection of deoxyribonucleic acid at ultralow concentrations by SERRS. Anal. Chem. 69, 4703–4707.Google Scholar
  114. 114.
    Dou, X., Yamaguchi, Y., Yamamoto, H., Doi, S., and Ozaki, Y. (1998) NIR SERS detection of immune reaction on gold colloid particles without bound/free antigen separation. J. Raman Spectrosc. 29, 739–742.Google Scholar
  115. 115.
    Ni, J., Lipert, R. J., Dawson, G. B., and Porter, M. D. (1999) Immunoassay readout method using extrinsic Raman labels adsorbed on immunogold colloids. Anal. Chem. 71, 4903–4908.PubMedGoogle Scholar
  116. 116.
    Rohr, T. E., Cotton, T., Fan, N., and Tarcha, P. J. (1989) Immunoassay employing surface-enhanced Raman-spectroscopy. Anal. Biochem. 182, 388–398.PubMedGoogle Scholar
  117. 117.
    Grabbe, E. S. and Buck, R. P. (1989) Surface-enhanced Raman-spectroscopic investigation of human immunoglobulin-G adsorbed on a silver electrode. J. Am. Chem. Soc. 111, 8362–8366.Google Scholar
  118. 118.
    Hawi, S. R., Rochanakij, S., Adar, F., Campbell, W. B., and Nithipatikom, K. (1998) Detection of membrane-bound enzymes in cells using immunoassay and Raman microspectroscopy. Anal. Biochem. 259, 212–217.PubMedGoogle Scholar
  119. 119.
    Dou, X., Takama, T., Yamaguchi, Y., Yamamoto, H., and Ozaki, Y. (1997) Enzyme immunoassay utilizing surface-enhanced Raman scattering of the enzyme reaction product. Anal. Chem. 69, 1492–1495.Google Scholar
  120. 120.
    Hirsch, L. R., Jackson, J. B., Lee, A., Halas, N. J., and West, J. L. (2003) A whole blood immunoassay using gold nanoshells. Anal. Chem. 75, 2377–2381.PubMedGoogle Scholar
  121. 121.
    Mulvaney, S. P., Musick, M. D., Keating, C. D., and Natan, M. J. (2003) Glass-coated, analyte-tagged nanoparticles: A new tagging system based on detection with surface-enhanced Raman scattering. Langmuir 19, 4784–4790.Google Scholar
  122. 122.
    Doering, W. E. and Ni, S. M. (2003) Spectroscopic tags using dye-embedded nanoparticles and surface-enhanced Raman scattering. Anal. Chem. 75, 6171–6176.PubMedGoogle Scholar
  123. 123.
    Sequaris, J. M. L. and Koglin, E. (1987) Direct analysis of high-performance thin-layer chromatography spots of nucleic purine derivatives by surface-enhanced raman-scattering spectrometry. Anal. Chem. 59, 525–527.PubMedGoogle Scholar
  124. 124.
    Koglin, E. and Sequaris, J. M. (1986) Interaction of proflavine with DNA studied by colloid surface enhanced resonance Raman-spectroscopy. J. Mol. Struct. 141, 405–409.Google Scholar
  125. 125.
    Koglin, E., Sequaris, J. M., and Valenta, P. (1980) Surface Raman-spectra of nucleic-acid components adsorbed at a silver electrode. J. Mol. Struct. 60, 421–425.Google Scholar
  126. 126.
    Koglin, E., Sequaris, J. M., and Valenta, P. (1982) Surface enhanced Raman-spectroscopy of nucleic-acid bases on Ag electrodes. J. Mol. Struct. 79, 185–189.Google Scholar
  127. 127.
    Kim, U. J., Shizuya, H., Deaven, L., Chen, X. N., Korenberg, J. R., and Simon, M. I. (1995) Selection of a sublibrary enriched for a chromosome from total human bacterial artificial chromosome library using DNA from flow-sorted chromosomes as hybridization probes. Nucleic Acids Res. 23, 1838–1839.PubMedGoogle Scholar
  128. 128.
    Kim, U. J., Birren, B. W., Slepak, T., Mancino, V., Boysen, C., Kang, H. L., Simon, M. I., and Shizuya, H. (1996) Construction and characterization of a human bacterial artificial chromosome library. Genomics 34, 213–218.PubMedGoogle Scholar
  129. 129.
    Kim, U. J., Shizuya, H., Kang, H. L., et al. (1996) A bacterial artificial chromosome-based framework contig map of human chromosome 22q. PNAS 93, 6297–6301.PubMedGoogle Scholar
  130. 130.
    Boncheva, M., Scheibler, L., Lincoln, P., Vogel, H., and Akerman, B. (1999) Design of oligonucleotide arrays at interfaces. Langmuir 15, 4317–4320.Google Scholar
  131. 131.
    Pohl, D. W., Denk, W., and Lanz, M. (1984) Optical stethoscopy—image recording with resolution lambda/20. Appl. Phys. Lett. 44, 651–653.Google Scholar
  132. 132.
    Betzig, E., Trautman, J. K., Harris, T. D., Weiner, J. S., and Kostelak, R. L. (1991) Breaking the diffraction barrier—optical microscopy on a nanometric scale. Science 251, 1468–1470.PubMedGoogle Scholar
  133. 133.
    Bian, R. X., Dunn, R. C., and Xie, X. S. (1995) Single molecule emission characteristics in near-field microscopy. Phys. Rev. Lett. 75, 4772–4775.PubMedGoogle Scholar
  134. 134.
    Gresillon, S., Aigouy, L., Boccara, A. C., et al. (1999) Experimental observation of localized optical excitations in random metal-dielectric films. Phys. Rev. Lett. 82, 4520–4523.Google Scholar
  135. 135.
    Emory, S. R. and Nie, S. (1997) Surface-enhanced Raman spectroscopy on single silver nanoparticles. Anal. Chem. 69, 2631–2635.Google Scholar
  136. 136.
    Xu, H. X., Bjerneld, E. J., Kall, M., and Borjesson, L. (1999) Spectroscopy of single hemoglobin molecules by surface enhanced Raman scattering. Phys. Rev. Lett. 83, 4357–4360.Google Scholar
  137. 137.
    Bjerneld, E. J., Foldes-Papp, Z., Kall, M., and Rigler, R. (2002) Single-molecule surface-enhanced Raman and fluorescence correlation spectroscopy of horse-radish peroxidase. J. Phys. Chem. B 106, 1213–1218.Google Scholar
  138. 138.
    Byassee, T. A., Chan, W. C. W., and Nie, S. (2000) Probing single molecules in single living cells. Anal. Chem. 72, 5606–5611.PubMedGoogle Scholar
  139. 139.
    Kneipp, K., Haka, A. S., Kneipp, H., et al. (2002) Surface-enhanced Raman spectroscopy in single living cells using gold nanoparticles. Appl. Spectrosc. 56, 150–154.Google Scholar
  140. 140.
    Yan, F., Wabuyele, M. B., Griffin, G. D., and Vo-Dinh, T. (2004) Targeted SERS nanoparticles for intracellular sensing. PittCon 2004, Chicago, IL. March 9–12.Google Scholar

Copyright information

© Humana Press Inc., Totowa, NJ 2005

Authors and Affiliations

  • Tuan Vo-Dinh
    • 1
  • Fei Yan
    • 2
  • David L. Stokes
    • 2
  1. 1.Center for Advanced Biomedical Photonics, Life Sciences DivisionOak Ridge National LaboratoryOak Ridge
  2. 2.Center for Advanced Biomedical PhotonicsOak Ridge National LaboratoryOak Ridge

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