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DNA Vaccines pp 439-449 | Cite as

Development of Female Contraceptive Vaccine Through DNA Inoculation of Human Chorionic Gonadotropin Beta Subunit (hCGß)

  • Fu-chun Zhang
  • Ni Wang
  • Dong-mei Liu
  • Youli Jian
  • You-zhen Chen
  • Xiao-zhou Shen
  • Yong-qing Cao
  • Bin Wang
Part of the Methods in Molecular Medicine™ book series (MIMM, volume 29)

Abstract

Human chorionic gonadotropin (hCG) has been considered as a primary target molecule for a contraceptive vaccine by the World Health Organization because of its physiological and temporal specificity. hCG is an essential factor for the successful implantation and establishment of early pregnancy. For a decade, the most advanced works in development of a contraceptive vaccine have been concentrated on polypeptide based vaccines targeted directly against hCG. Although many studies have reached the stage of clinical testing using a number of prototype vaccines based on different parts of hCG molecule, their efficacy has been disappointing (1, 2, 3, 4).

Keywords

Vaginal Plug Contraceptive Vaccine Sodium Perborate Prototype Vaccine Human Chorionic Gonadotropin Beta Subunit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Humana Press Inc., Totowa, NJ 2000

Authors and Affiliations

  • Fu-chun Zhang
    • 1
  • Ni Wang
    • 1
  • Dong-mei Liu
    • 1
  • Youli Jian
    • 1
  • You-zhen Chen
    • 1
  • Xiao-zhou Shen
    • 1
  • Yong-qing Cao
    • 1
  • Bin Wang
    • 2
  1. 1.State Key Laboratory of Reproductive Biology, Institute of ZoologyChinese Academy of SciencesBeijingChina
  2. 2.Beijing Cathay Biotechnology Co. Ltd.BeijingChina

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