Opioid Research pp 157-183

Part of the Methods in Molecular Biology™ book series (MIMM, volume 84)

Opioid Receptor Oligomerization

Detection and Functional Characterization of Interacting Receptors
  • Ivone Gomes
  • Lakshmi A. Devi
  • Julija Filipovska


Opioid receptors are members of the G-protein coupled receptor (GPCR) family characterized by the presence of seven transmembrane domains. These receptors are classified as mu (μ), delta (δ), and kappa (κ). Activation of these receptors leads to uncoupling of the inhibitory G-proteins (Gi) followed by the activation of multiple signal transduction pathways including the inhibition of adenylyl cyclase, modulation of inwardly rectifying K+ channels or voltage-dependent calcium channels and regulation of mitogen-activated protein (MAP) kinase activity (1, 2, 3, 4).


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Copyright information

© Humana Press Inc. 2003

Authors and Affiliations

  • Ivone Gomes
    • 1
  • Lakshmi A. Devi
    • 1
  • Julija Filipovska
    • 2
  1. 1.Department of Pharmacology and Biological ChemistryNew York
  2. 2.Department of Biochemistry and Molecular BiologyUniversity of BarcelonaBarcelonaSpain

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