Functional Genomics

Volume 224 of the series Methods in Molecular Biology pp 111-136

Statistical Issues in cDNA Microarray Data Analysis

  • Gordon K. SmythAffiliated withWalter and Eliza Hall Institute of Medical Research
  • , Yee Hwa YangAffiliated withDivision of Biostatistics, University of California
  • , Terry SpeedAffiliated withWalter and Eliza Hall Institute of Medical ResearchDepartment of Statistics, University of California-Berkeley

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Statistical considerations are frequently to the fore in the analysis of microarray data, as researchers sift through massive amounts of data and adjust for various sources of variability in order to identify the important genes among the many that are measured. This chapter summarizes some of the issues involved and provides a brief review of the analysis tools that are available to researchers to deal with these issues.