PCR Mutation Detection Protocols

Volume 187 of the series Methods in Molecular Biology pp 151-163

SSCP/Heteroduplex Analysis

  • Andrew J. WallaceAffiliated withDNA Laboratory, Department of Medical Genetics, St. Mary’s Hospital

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Single-strand conformation (SSCP) and heteroduplex analysis are separate mutation scanning methods in their own right. They are, however, unusual in that they can be carried out simultaneously on a single gel.