Malaria Methods and Protocols pp 103-116

Part of the Methods in Molecular Medicine™ book series (MIMM, volume 72)

Genotyping of Plasmodium spp.

Nested PCR
  • Georges Snounou


It is now established that Plasmodium falciparum parasites found in any one area are highly diverse and that individual hosts, vertebrate and insect, are often concurrently infected by multiple parasite lines (for example, seerefs.1-4). Different parasite lines of the same Plasmodium species are also known to vary substantially with respect to parameters such as the parasitological and clinical course of the infection, the pattern of recrudescence, immunological cross-reactivity, susceptibility to drugs, and transmissibility by various vector species. The relationship between the complexity of the parasite populations and such pathological, immunological, and epidemiological factors is poorly understood and clearly merits further investigation (for example, seerefs.4-16).


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Copyright information

© Humana Press Inc. 2002

Authors and Affiliations

  • Georges Snounou
    • 1
  1. 1.Bio-medical ParasitologyInstitut PasteurParisFrance

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