Genomics Protocols pp 309-321

Part of the Methods in Molecular Biology™ book series (MIMB, volume 175) | Cite as

Expression Profiling by Systematic High-Throughput In Situ Hybridization to Whole-Mount Embryos

  • Nicolas Pollet
  • Christof Niehrs

Abstract

The genome of a given organism is considered in biology as the fundamental invariant (1). It is virtually the same throughout lifetime and, to a lesser extent, over generations. By contrast, genetic information is expressed in complex and ever-changing temporal and spatial patterns throughout development and differentiation. The description and analysis of these patterns is crucial to elucidate the functions of genes and to understand the network of genetic interactions that underlies the process of normal development.

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Copyright information

© Humana Press Inc., Totowa, NJ 2001

Authors and Affiliations

  • Nicolas Pollet
    • 1
  • Christof Niehrs
    • 1
  1. 1.Division of Molecular EmbryologyDeutsches KrebsforschungszentrumHeidelbergGermany

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