Adenovirus-Mediated Drug-Sensitivity Gene Therapy for Hepatocellular Carcinoma

  • Fumihiko Kanai
  • Makoto Ohashi
  • Paola A. Marignani
  • Yasushi Shiratori
  • Hirofumi Hamada
  • Masao Omata
Part of the Methods in Molecular Medicine™ book series (MIMM, volume 45)


Selective gene therapy represents a potent approach in cancer treatment that utilizes a cell’s own nontoxic suicide genes. Currently, the suicide genes under investigation mediate sensitivity by encoding viral or bacterial enzymes that convert inactive prodrug into toxic antimetabolites that inhibit nucleic acid synthesis (1,2).


Adenovirus Vector Uninfected Cell Bystander Effect Suicide Gene Cytosine Deaminase 
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Copyright information

© Humana Press Inc., Totowa, NJ 2000

Authors and Affiliations

  • Fumihiko Kanai
    • 1
    • 2
  • Makoto Ohashi
    • 2
  • Paola A. Marignani
    • 3
    • 1
  • Yasushi Shiratori
    • 2
  • Hirofumi Hamada
    • 4
  • Masao Omata
    • 2
  1. 1.Department of Cell BiologyHarvard Medical SchoolBoston
  2. 2.Department of GastroenterologyUniversity of TokyoTokyoJapan
  3. 3.Division of Signal Transduction,Department of Medicine,Beth Israel Deaconess Medical Center and Department of Cell BiologyHarvard Medical SchoolBostonMA
  4. 4.Department of Molecular Biotherapy Research, Cancer Chemotherapy Center, Cancer InstituteJapanese Foundation for Cancer ResearchTokyoJapan

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