Measurement of Sulfate in Mucins
The sulfation of the terminal sugar residues of mucins is a common and extensive posttranslational event that greatly influences the ultimate viscoelastic properties of mucin. Highly sulfated and/or sialylated mucins comprise a considerable proportion of the mucous layers of the gastrointestinal, respiratory, and reproductive tracts, and have been demonstrated to be associated with some pathological conditions and patho-genesis (1, 2, 3, 4). The precise biological roles for glycan sulfation are largely unknown; however, several groups have demonstrated discrete biological roles for specific instances of glycan sulfation of non-mucin glycoproteins. These roles include the control of the circulatory half-life of human luteinizing hormone, symbiotic interactions of leguminous plants and nitrogen-fixing bacteria, and the targeting of lymphocytes to lymph nodes (5).
KeywordsInorganic Sulfate Curve Gradient Sulfate Peak Glycan Sulfation Human Luteinizing Hormone
- 6.Harrison M. J., Nouwens A. S., Jardine D., Zachara N. E., Gooley A. A., Nevalainen H., and Packer N. H. Eur. J. Biochem. 256, 119–127.Google Scholar