Protocol

Cytochrome P450 Protocols

Volume 107 of the series Methods in Molecular Biology™ pp 279-294

Hepatocyte Cultures in Drug Metabolism and Toxicological Research and Testing

  • Vera RogiersAffiliated withDepartment of Toxicology, Vrije Universiteit Brussel
  • , Antoine VercruysseAffiliated withDepartment of Toxicology, Vrije Universiteit Brussel

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Abstract

The safety for man of new pharmaceuticals is ensured by in vivo testmg, at a first stage by using experimental animals and later, in clmrcal trials, by administration of the drugs to human volunteers (1). On a global scale, ammal-based in vivo testing mvolves a large number of vertebrates, partrcularly rodents (2).