Generation of Closed Transverse Fractures in Small Animals

  • Anthony De Giacomo
  • Elise F. Morgan
  • Louis C. Gerstenfeld
Part of the Methods in Molecular Biology book series (MIMB, volume 1130)


The most common procedure that has been developed for use in rats and mice to model fracture healing is described. The nature of the regenerative processes that may be assessed and the types of research questions that may be addressed with this model are briefly outlined. The detailed surgical protocol to generate closed simple transverse fractures is presented, and general considerations when setting up an experiment using this model are described.


Fracture Healing Surgical Model Rodent 



This work is supported by NIH Grants AR056637 and AR062642.


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Copyright information

© Springer Science+Business Media, LLC 2014

Authors and Affiliations

  • Anthony De Giacomo
    • 1
  • Elise F. Morgan
    • 1
  • Louis C. Gerstenfeld
    • 1
  1. 1.Boston University School of MedicineBostonUSA

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