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G Protein-Coupled Receptor Genetics pp 23–43Cite as

Examining the Dynamic Evolution of G Protein-Coupled Receptors

Part of the Methods in Pharmacology and Toxicology book series (MIPT)

Abstract

The valuable source of large-scale genomic information initiated attempts to identify the origin(s) of G protein-coupled receptors (GPCR), count and categorize those genes, and follow their evolutionary history. Being present in fungi, plants, and unicellular eukaryotes, GPCR must have evolved before the plant-fungi-animal split about 1.5 billion years ago. Phylogenetic analyses revealed several kinds of evolutionary patterns that occurred during GPCR evolution including one-to-one orthologous relationships, species-specific gene expansion, and episodic duplication of the entire GPCR repertoire in certain species lineages. These data document the highly dynamic process of birth and death of GPCR genes since hundreds of millions of years. Genetic drift and selective forces have shaped the individual structure of a given receptor gene but also of the species-specific receptor repertoire – a process that is still ongoing. These processes have left footprints in the genomic sequence that can be detected by bioinformatic methods and may help to interpret receptor function in the light of a given species in its environment. Reasonable intraspecies sequence variability in GPCR is either physiologically tolerated or promotes individual phenotypes and adaptation, but also susceptibilities for diseases. Therefore, the impact of GPCR variants in epistatic networks will be an important task of future GPCR research. The chapter summarizes evolutionary processes working on GPCR genes and sheds light on their consequences at the levels of receptor structure and function.

Keywords

  • G protein-coupled receptors
  • GPCR
  • Selection
  • Genetic variability

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Acknowledgments

My special thanks go to all current and past members of our group who worked with us on GPCR structure-function relationships and GPCR evolution over the years. Most of our work was supported by the German Research Foundation (DFG) and the Germany Federal Ministry of Education and Research (BMBF).

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Authors and Affiliations

  1. Department of Molecular Biology, Umeå University and University of Leipzig, Umeå, Sweden

    Claudia Stäubert

  2. Institute of Biochemistry, Faculty of Medicine, University of Leipzig, Leipzig, Germany

    Diana Le Duc & Torsten Schöneberg

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  1. Claudia Stäubert
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  2. Diana Le Duc
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  3. Torsten Schöneberg
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Editors and Affiliations

  1. Oklahoma State University, Tulsa, Oklahoma, USA

    Craig W. Stevens

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Stäubert, C., Le Duc, D., Schöneberg, T. (2014). Examining the Dynamic Evolution of G Protein-Coupled Receptors. In: Stevens, C. (eds) G Protein-Coupled Receptor Genetics. Methods in Pharmacology and Toxicology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-779-2_2

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  • DOI: https://doi.org/10.1007/978-1-62703-779-2_2

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-778-5

  • Online ISBN: 978-1-62703-779-2

  • eBook Packages: Springer Protocols

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