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Mouse Model of Post-arthroplasty Staphylococcus epidermidis Joint Infection

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Staphylococcus Epidermidis

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1106))


Animal models are invaluable tools for translational research, allowing investigators to recapitulate observed clinical scenarios within the laboratory that share attributes with human disease. Here, we describe a mouse model of post-arthroplasty Staphylococcus epidermidis joint infection which mimics human disease and may be utilized to explore the complex series of events during staphylococcal implant-associated infections by identifying key immunological, bacterial, and/or therapeutic mechanisms relevant to these persistent infections.

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This work was supported by the NIH National Institute of Allergy and Infectious Disease (NIAID) P01 AI083211 to Tammy Kielian.

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Scherr, T.D., Lindgren, K.E., Schaeffer, C.R., Hanke, M.L., Hartman, C.W., Kielian, T. (2014). Mouse Model of Post-arthroplasty Staphylococcus epidermidis Joint Infection. In: Fey, P. (eds) Staphylococcus Epidermidis. Methods in Molecular Biology, vol 1106. Humana Press, Totowa, NJ.

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-735-8

  • Online ISBN: 978-1-62703-736-5

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