Statistical Design and Evaluation of Biomarker Studies

  • Kevin K. Dobbin
Part of the Methods in Molecular Biology book series (MIMB, volume 1102)


We review biostatistical aspects of biomarker studies, including design and analysis issues, covering the range of settings required for translational research—from early exploratory studies through clinical trials.

Key words

Translational research Experimental design Sample size Power 



This work was supported by the Distinguished Cancer Scholars grant program of the Georgia Research Alliance.


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Copyright information

© Springer Science+Business Media, New York 2014

Authors and Affiliations

  • Kevin K. Dobbin
    • 1
  1. 1.Department of Epidemiology and BiostatisticsCollege of Public Health, University of GeorgiaAthensUSA

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