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B7-H Abnormalities in Melanoma and Clinical Relevance

  • Barbara Seliger
Part of the Methods in Molecular Biology book series (MIMB, volume 1102)

Abstract

Melanoma have been shown to escape immune surveillance by different mechanisms such as loss of HLA class I antigens, upregulation of nonclassical HLA-G antigen and Fas, increased secretion of immune suppressive cytokines and metabolites as well as altered expression of co-stimulatory and coinhibitory signals. Recently, an important role of B7-H1 and B7-H4 in the immune escape of melanoma has been described. High mRNA and/or protein expression levels of these coinhibitory molecules were detected in both melanoma cell lines and melanoma lesions when compared to melanocytes. However, their clinical relevance is currently controversially discussed regarding a correlation of B7-H family members with tumor grading and staging as well as survival of patients in melanoma.

Key words

MHC antigens Coinhibitory molecules Immune escape Melanoma 

Abbreviations

APC

Antigen presenting cell

BTLA

B- and T-lymphocyte attenuator

CTL

Cytotoxic T lymphocyte

CTLA4

Cytotoxic T-lymphocyte antigen 4

HLA

Human leukocyte antigen

IFN

Interferon

mAb

Monoclonal antibody

MFI

Mean specific fluorescence intensity

PBS

Phosphate buffered saline

PD1

Programmed cell death

TCR

T cell receptor

TIL

Tumor-infiltrating lymphocyte

β2-m

β2-Microglobulin

Notes

Acknowledgements

This work was supported from grants of the Mildred Scheel Cancer Foundation, the Wilhelm Sander Foundation and the intramural Wilhelm Roux Program.

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Copyright information

© Springer Science+Business Media, New York 2014

Authors and Affiliations

  • Barbara Seliger
    • 1
  1. 1.Institute of Medical Immunology, Martin Luther University Halle-WittenbergHalleGermany

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