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Peptide Modifications to Increase Metabolic Stability and Activity pp 47–60Cite as

Peptoids and Peptide–Peptoid Hybrid Biopolymers as Peptidomimetics

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1081))

Abstract

Peptoids (oligomers of N-substituted glycine residues) and peptide–peptoid hybrid polymers (peptomers) are interesting classes of compounds mimicking structure and function of biologically active peptides. The oligomeric peptidomimetics such as peptoids are particularly important compounds since they provide access to an enormous molecular diversity, by variation of the building blocks. The modular structure of peptoids, ease of synthesis, and high compatibility with existing peptide chemistry synthetic protocols, make peptoids and peptoid-containing peptidomimetics ideal tools for structure–activity and drug discovery related studies.

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Authors and Affiliations

  1. Torrey Pines Institute for Molecular Studies, Port St. Lucie, FL, USA

    Maciej J. Stawikowski

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  1. Maciej J. Stawikowski
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Editors and Affiliations

  1. Torrey Pines Institute for Molecular Stu, Port St. Lucie, Florida, USA

    Predrag Cudic

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Stawikowski, M.J. (2013). Peptoids and Peptide–Peptoid Hybrid Biopolymers as Peptidomimetics. In: Cudic, P. (eds) Peptide Modifications to Increase Metabolic Stability and Activity. Methods in Molecular Biology, vol 1081. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-652-8_4

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  • DOI: https://doi.org/10.1007/978-1-62703-652-8_4

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-651-1

  • Online ISBN: 978-1-62703-652-8

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