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The Use of Calorie Restriction Mimetics to Study Aging

Protocol
First Online:
Part of the Methods in Molecular Biology book series (MIMB, volume 1048)

Abstract

Calorie restriction (CR) has a variety of effects on extending lifespan and delaying the onset of age-related diseases, and it is accepted as the only established experimental antiaging intervention. Several pharmacological agents that can replicate the beneficial effects of CR, called calorie restriction mimetics (CRMs), have been identified. The nutrient-sensing pathways including those involving sirtuins (especially SIRT1) and mammalian target of rapamycin (mTOR) may regulate the physiology of CR, and candidate CRMs that modulate these specific pathways have been identified and investigated using animal models. In this chapter, we focus on candidate CRMs including sirtuin-activating compounds (STACs) and mTOR inhibitors, their slowing of aging, and methods for evaluation of lifespan and metabolic disorders.

Key words

Calorie restriction Calorie restriction mimetics (CRMs) SIRT1 Resveratrol Sirtuin-activating compounds (STACs) mTOR Rapamycin 
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Notes

Acknowledgements

This work was supported by a Grant from Novo Nordisk Pharma, a Grant-in-Aid for Scientific Research (C) (24591218), and a Grant for Promoted Research from Kanazawa Medical University (S2012-4) to M. Kitada and by Grants for Collaborative Research (C2012-1) and Specially Promoted Research from Kanazawa Medical University (SR2012-06) and the Fourth Annual Research Award Grant of Japanese Society of Anti-Aging Medicine to D. Koya.

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Copyright information

© Springer Science+Business Media, New York 2013

Authors and Affiliations

  1. 1.Diabetology & EndocrinologyKanazawa Medical UniversityUchinadaJapan

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