Cyclopentane Peptide Nucleic Acids

  • Ethan A. Englund
  • Ning Zhang
  • Daniel H. Appella
Part of the Methods in Molecular Biology book series (MIMB, volume 1050)


Incorporating a cyclopentane ring into the two-carbon unit of a peptide nucleic acid backbone increases its binding affinity to complementary nucleic acid sequences. This approach is a general method to improve binding and can be applied at either purine or pyrimidine bases.

Key words

PNA Cyclopentane Nucleic acid 


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Copyright information

© Springer Science+Business Media, New York 2014

Authors and Affiliations

  • Ethan A. Englund
    • 1
  • Ning Zhang
    • 1
  • Daniel H. Appella
    • 1
  1. 1.Section on Synthetic Bioactive Molecules, Laboratory of Bioorganic ChemistryNIDDK, NIH, DHHSBethesdaUSA

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