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Cell Mediated Rejection

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Transplantation Immunology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1034))

Abstract

Rejection is the major barrier to successful transplantation and usually results from the integration of multiple mechanisms. Activation of elements of the innate immune system, triggered as a consequence of tissue injury sustained during cell isolation or organ retrieval as well as ischemia–reperfusion, will initiate and amplify the adaptive response. For cell mediated rejection, T cells require multiple signals for activation, the minimum being two signals; antigen recognition and costimulation. The majority of B cells require help from T cells to initiate alloantibody production. Antibodies reactive to donor HLA molecules, minor histocompatibility antigens, endothelial cells, red blood cells, or autoantigens can trigger or contribute to rejection early as well as late after transplantation.

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Acknowledgments

The work from the authors’ own laboratory described in this review was supported by grants from The Wellcome Trust, Medical Research Council, British Heart Foundation, Kidney Research UK, Garfield Weston Trust, and European Union through the Indices of Tolerance, RISET, OPTISTEM, TRIAD, and BioDRIM projects.

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Authors and Affiliations

  1. Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, Oxford, UK

    Kathryn J. Wood, Masaaki Zaitsu & Ryoichi Goto

Authors
  1. Kathryn J. Wood
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  2. Masaaki Zaitsu
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  3. Ryoichi Goto
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Editor information

Editors and Affiliations

  1. , Immunogenetics Laboratory, Johns Hopkins University School of Medic, E. Monument Street 2041, Baltimore, 21205, Maryland, USA

    Andrea A. Zachary

  2. , Immunogenetics Laboratory, Johns Hopkins University School of Medic, E. Monument Street 2041, Baltimore, 21205, Maryland, USA

    Mary S. Leffell

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Wood, K.J., Zaitsu, M., Goto, R. (2013). Cell Mediated Rejection. In: Zachary, A., Leffell, M. (eds) Transplantation Immunology. Methods in Molecular Biology, vol 1034. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-493-7_3

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  • DOI: https://doi.org/10.1007/978-1-62703-493-7_3

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-492-0

  • Online ISBN: 978-1-62703-493-7

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