Antiviral Methods and Protocols pp 373-382
In Vivo Evaluation of Antiviral Compounds on Respiratory Syncytial Virus Using a Juvenile Vervet Monkey (Chlorocebus pygerythrus) Infection Model
Several animal models with varying susceptibilities to respiratory syncytial virus (RSV) infection have been developed to study the specific aspects of RSV disease. Many of these models are used for testing antiviral compounds or in vaccine efficacy studies during preclinical evaluation. In this chapter, we describe the study design of an efficacy study of an RSV inhibitor, performed in a juvenile vervet monkey model for RSV.
Key wordsRespiratory syncytial virus Monkey model RSV inhibitor Animal infection model
- 10.Houspie L, Ipsas G, Keyaerts E et al (2013) Juvenile vervet monkey model for human respiratory syncytial virus infection (manuscript in preparation)Google Scholar