Reliable Methods for Silica Coating of Au Nanoparticles

  • Isabel Pastoriza-Santos
  • Luis M. Liz-Marzán
Part of the Methods in Molecular Biology book series (MIMB, volume 1025)


The inherent properties of silica, such as optical transparency, high biocompatibility, chemical and colloidal stability, controllable porosity, and easy surface modification, provide silica materials with a tremendous potential in biomedicine. Therefore, the coating of Au nanoparticles with silica largely contributes to enhance the important applications of metal nanoparticles in biomedicine. We describe in this chapter a number of reliable strategies that have been reported for silica coating of different types of Au nanoparticles. All descriptions are based on tested protocols and are expected to provide a reference for scientists with an interest in this field.

Key words

Au nanoparticles Silica coating Core-shell Surface modification Optical properties 



This work has been funded by the Spanish Xunta de Galicia/FEDER (grant 10 PXIB 314 218 PR) and MINECO/FEDER (grant MAT2010-15374). LML-M acknowledges the ERC for an Advanced grant (NANODIRECT, grant number CP-FP 213948–2). The authors would like to thank Sara Abalde-Cela, Cristina Fernández-López, Sergio Rodal and Jorge Pérez-Juste, Ana M. Sánchez-Iglesias for their contributions and comments.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Isabel Pastoriza-Santos
    • 1
  • Luis M. Liz-Marzán
    • 2
  1. 1.Departamento de Química FísicaCampus Universitario, Universidade de VigoBilbaoSpain
  2. 2.CIC biomaGUNEDonostia - San, SebastiánSpain

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