Abstract
Pharmacogenomics studies how the variations of the individuals’ genetic makeup are correlated with a person’s response to certain drugs in relation to the therapeutic efficiency, clinical outcome, or even survival, and how they affect drug metabolism, transport, or clearance. Yet, since the incidence of these polymorphisms, being either single-point variations or small insertions/deletions, varies among different populations, a systematic collection and documentation of these variations is warranted, in order to facilitate implementation of pharmacogenomics in different populations. Here we review the existing electronic databases related to pharmacogenomics and pay particular attention in the description of the pharmacogenomics module Frequency of Inherited Disorders database (FINDbase), which documents curated allelic frequency data pertaining to 144 pharmacogenomics markers across 14 genes, representing approximately 87,000 individuals from 150 populations and ethnic groups worldwide. Long-term sustainability of these resources aims to contribute to the design, development, and implementation of pharmacogenomics testing towards the application of personalized approaches in medical treatment.
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Acknowledgments
We wish to thank Sjozef van Baal for providing the building blocks for FINDbase and FINDbase-PGx and for his continuous efforts. A part of our own work has been funded by the European Commission [ITHANET (FP6-026539), EuroGenTest (FP6-512148), and GEN2PHEN (FP7-200754) projects], and the Golden Helix Institute of Biomedical Research. Dr. Marianthi Georgitsi is the recipient of a State Scholarship Foundation (IKY) postdoctoral grant.
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Georgitsi, M., Patrinos, G.P. (2013). Genetic Databases in Pharmacogenomics: The Frequency of Inherited Disorders Database (FINDbase). In: Innocenti, F., van Schaik, R. (eds) Pharmacogenomics. Methods in Molecular Biology, vol 1015. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-435-7_21
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DOI: https://doi.org/10.1007/978-1-62703-435-7_21
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