Abstract
Oncoproteins encoded by dominant oncogenes have long been considered as targets for chemotherapeutic intervention. However, oncogenic transcription factors have often been dismissed as “undruggable.” Members of Myc family of transcription factors have been identified as promising targets for cancer chemotherapy in multiple publications reporting the requirement of Myc proteins for maintenance of almost every type of tumor. Here, we describe cell-based approaches to identify c-Myc small molecule inhibitors by screening complex libraries of diverse small molecules based on Myc functionality and specificity.
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Acknowledgments
This work was supported by NIH R01 CA120244 and ACS RSG-10-121-01 grants to M.A.N., and by CINSW and NHMRC grants to M.H. and M.D.N.
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Burkhart, C.A., Haber, M., Norris, M.D., Gudkov, A.V., Nikiforov, M.A. (2013). Cell-Based Methods for the Identification of MYC-Inhibitory Small Molecules. In: Soucek, L., Sodir, N. (eds) The Myc Gene. Methods in Molecular Biology, vol 1012. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-429-6_18
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DOI: https://doi.org/10.1007/978-1-62703-429-6_18
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Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-62703-428-9
Online ISBN: 978-1-62703-429-6
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