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The Myc Gene pp 1–6Cite as

The Myc World Within Reach

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1012))

Abstract

Myc is a transcriptional coordinator of a wide range of intracellular and extracellular processes required for cell proliferation. These processes are tightly regulated in physiological conditions but hijacked when Myc is oncogenically activated. In fact, aberrantly elevated and/or deregulated activity of Myc is associated with the majority of human cancers. Several switchable mouse transgenic models have been developed and provided insights on the role of Myc in maintaining multiple aspects of the tumor phenotype, indicating that Myc inhibition would constitute an effective and broadly applicable anticancer therapeutic strategy. This issue of “The Myc gene: Methods and Protocols” provides a rich collection of techniques developed or routinely used by Myc investigators and serves as an invaluable resource for exploring the pleiotropic and still puzzling Myc biological functions.

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Author information

Authors and Affiliations

  1. Department of Biochemistry, University of Cambridge, Cambridge, UK

    Nicole M. Sodir

  2. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain

    Laura Soucek

Authors
  1. Nicole M. Sodir
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  2. Laura Soucek
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Editor information

Editors and Affiliations

  1. Fundació Vall d'Hebron Institute of Onco, Barcelona, Spain

    Laura Soucek

  2. Department of Biochemistry Sanger Building, University of Cambridge, Cambridge, United Kingdom

    Nicole M. Sodir

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Sodir, N.M., Soucek, L. (2013). The Myc World Within Reach. In: Soucek, L., Sodir, N. (eds) The Myc Gene. Methods in Molecular Biology, vol 1012. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-429-6_1

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  • DOI: https://doi.org/10.1007/978-1-62703-429-6_1

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-428-9

  • Online ISBN: 978-1-62703-429-6

  • eBook Packages: Springer Protocols

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