Haemostasis pp 49-71 | Cite as

Specimen Requirements for the Haemostasis Laboratory

  • Linda J. Stang
  • Lesley G. Mitchell
Part of the Methods in Molecular Biology book series (MIMB, volume 992)


Sample integrity is one of the most important details to consider for the production of quality results in the laboratory. Many factors have the potential to adversely affect the sample: intrinsic patient characteristics (caused by the underlying malady and/or treatment, incorrect patient preparation, etc.), difficult or incorrectly performed collection of sample, correct timing of sample collection relative to drug administration, incorrect processing and transport within the laboratory—just to name a few. This chapter outlines standard common requirements with explanations as a basis for those limitations, and practical laboratory advice to attain and maintain dependable samples.

Key words

Blood sampling Plasma storage Blood sampling artifacts Sodium citrate Vacutainers Sample stability Platelet-free plasma Hemolysis Lipemia Interference Diurnal variation 



In memory of my father, who stressed to his children the value of education and kind deeds, and from whom I learnt that a good day’s work can feed both your family and your mind. L. Stang.

Funding support was from the Canadian Institute of Health Research (L Mitchell Grant#114981).


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Copyright information

© Humana Press 2013

Authors and Affiliations

  • Linda J. Stang
    • 1
  • Lesley G. Mitchell
    • 2
  1. 1.Department of Laboratory Medicine and PathologyUniversity of Alberta HospitalEdmontonCanada
  2. 2.Hematology/Oncology, Department of PediatricsUniversity of AlbertaEdmontonCanada

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