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Haemostasis pp 171-180 | Cite as

Factor XIII Assays

  • Stephen Opat
  • Jenny Butler
  • Erica Malan
  • Elizabeth Duncan
  • Huyen A. M. Tran
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 992)

Abstract

Factor XIII (FXIII) deficiency is a rare cause of bleeding and pregnancy loss that is easily treated with plasma products. Reliable assays for FXIII are necessary not only for the diagnosis of deficiency state but also to guide prophylaxis and replacement therapy in patients during times of increased risk. Diagnostic tests for FXIII activity whilst not technically demanding have a number of pitfalls including limited sensitivity and overestimation of activity at the lower end. Despite these shortcomings the performance of these assays is adequate for the diagnosis and management of the majority of patients with clinically significant deficiency.

Key words

Factor XIII assay Coagulation factor 

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Copyright information

© Humana Press 2013

Authors and Affiliations

  • Stephen Opat
    • 1
  • Jenny Butler
    • 2
  • Erica Malan
    • 2
  • Elizabeth Duncan
    • 3
  • Huyen A. M. Tran
    • 1
  1. 1.Department of HaematologyMonash Medical CentreClaytonAustralia
  2. 2.Haematology LaboratoryMonash Medical CentreClaytonAustralia
  3. 3.Division of HaematologyInstitute of Medical and Veterinary ScienceAdelaideAustralia

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