Factor XIII Assays
Factor XIII (FXIII) deficiency is a rare cause of bleeding and pregnancy loss that is easily treated with plasma products. Reliable assays for FXIII are necessary not only for the diagnosis of deficiency state but also to guide prophylaxis and replacement therapy in patients during times of increased risk. Diagnostic tests for FXIII activity whilst not technically demanding have a number of pitfalls including limited sensitivity and overestimation of activity at the lower end. Despite these shortcomings the performance of these assays is adequate for the diagnosis and management of the majority of patients with clinically significant deficiency.
Key wordsFactor XIII assay Coagulation factor
- 10.Bolton-Maggs PH, Perry DJ, Chalmers EA, Parapia LA, Wilde JT, Williams MD, Collins PW, Kitchen S, Dolan G, Mumford AD (2004) The rare coagulation disorders–review with guidelines for management from the United Kingdom Haemophilia Centre Doctors’ Organisation. Haemophilia 10: 593–628PubMedCrossRefGoogle Scholar
- 11.Mitchell Lewis S, Bain BJ, Bates I (eds) (2006) Dacie and Lewis practical haematology, Vol. 1, 10th edn. Churchill Livingstone, PhiladelphiaGoogle Scholar
- 14.Dade-Behring (2005) Berichrom FXIII In: Reagents for the photometric determination of Factor XIII p6, Dade Behring, Marburg, GermanyGoogle Scholar
- 15.Colman RW (ed) (2006) Hemostasis and thrombosis, basic principles and clinical practice, Vol. 1, 5th edn. Lippincott, Williams & Wilkins, PhiladelphiaGoogle Scholar