Cerebral Malaria: Protection by Erythropoietin

  • Anne-Lise Bienvenu
  • Stephane Picot
Part of the Methods in Molecular Biology book series (MIMB, volume 982)


Cerebral malaria (CM) is still responsible for unacceptable death rate, while new antimalarial drugs were recently developed. CM pathophysiology shares essential biological features with cerebral ischemia. Because erythropoietin (Epo) was demonstrated to reduce mortality rate during experimental cerebral ischemia (1), in the early 2000, we wondered whether Epo could help to reduce the burden of CM. There is now evidence that Epo high doses could prevent early mortality during cerebral malaria. This evidence was obtained first using mice model of cerebral malaria, and later confirmed by prospective clinical trial in endemic area. High doses of Epo are needed to cross the blood–brain barrier (see Note 1) and to favor the cytoprotective versus hematopoietic effect of this pleiotropic cytokine (see Note 2).

Key words

Erythropoietin Cerebral malaria Neuronal apoptosis Endothelial apoptosis Murine model Neuroprotection CEPO Epo-biosimilars 


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Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  • Anne-Lise Bienvenu
    • 1
  • Stephane Picot
    • 1
  1. 1.Malaria Research Unit, SMITH ICBMS UMR CNRS, UCBL, INSA LyonLyonFrance

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