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Tissue-Protective Cytokines pp 213–225Cite as

ARA290 in a Rat Model of Inflammatory Pain

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 982))

Abstract

Chronic pain affects as many as one in five people. A proportion of patients with symptoms of neuropathic ­pain do not have clinical signs of any obvious tissue or nerve injury. Such patients include those with diffuse limb pain, back pain, and complex regional pain syndrome type 1. These patients remain a clinical enigma. However, through the development of the neuritis model, it has become apparent that local nerve inflammation in the absence of gross pathology (i.e., axonal degeneration and demyelination) may underlie part of the mechanisms of pain. In this chapter, we describe a method to induce the neuritis model. We also describe in detail a reliable method to test for mechanical allodynia and heat hyperalgesia. Data that demonstrates the potential benefits of the neuroprotective agent ARA290 in reducing pain behavior in the neuritis model are presented.

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Authors and Affiliations

  1. Brighton and Sussex Medical School, Falmer, Brighton, UK

    Andrew Dilley

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  1. Andrew Dilley
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Editors and Affiliations

  1. Medical School, Brighton and Sussex, Trafford Centre, Falmer, BN1 9RY, United Kingdom

    Pietro Ghezzi

  2. Leiden University Medical Center, Stille Rijn 11a, Leiden, 2312 DE, Netherlands

    Anthony Cerami

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Dilley, A. (2013). ARA290 in a Rat Model of Inflammatory Pain. In: Ghezzi, P., Cerami, A. (eds) Tissue-Protective Cytokines. Methods in Molecular Biology, vol 982. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-308-4_14

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  • DOI: https://doi.org/10.1007/978-1-62703-308-4_14

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-307-7

  • Online ISBN: 978-1-62703-308-4

  • eBook Packages: Springer Protocols

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