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Chiral Separations pp 209–220Cite as

Enantioseparations by High-Performance Liquid Chromatography Using Molecularly Imprinted Polymers

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 970))

Abstract

Molecularly imprinted polymers (MIPs) are becoming increasingly useful as chromatographic adsorbents for molecular separations, especially chiral separations, because they can be tailored to specifically recognize the target molecule including its stereochemistry. Traditionally formed MIPs (as described here) are stable under ambient conditions for years, take only days to make, and use relatively inexpensive components, with the possible exception of the template in some cases which can be reused after it is removed from the polymer to keep costs down. In addition to providing experimental details for typical synthetic methods to fabricate MIPs and pack them into HPLC columns, this chapter also gives an overview of the concepts of molecular imprinting method and discusses important factors for designing an effective imprinted polymer.

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Acknowledgments

The authors gratefully acknowledge funding from the National Science Foundation, grant CBET-0854105.

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Authors and Affiliations

  1. Department of Chemistry, Louisiana State University, Baton Rouge, LA, USA

    David A. Spivak

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  1. David A. Spivak
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Correspondence to David A. Spivak .

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Editors and Affiliations

  1. , Department of Pharmaceutical Chemistry, Friedrich-Schiller-University Jena, Philosophenweg 14, Jena, 07743, Germany

    Gerhard K. E. Scriba

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Spivak, D.A. (2013). Enantioseparations by High-Performance Liquid Chromatography Using Molecularly Imprinted Polymers. In: Scriba, G. (eds) Chiral Separations. Methods in Molecular Biology, vol 970. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-263-6_12

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  • DOI: https://doi.org/10.1007/978-1-62703-263-6_12

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-262-9

  • Online ISBN: 978-1-62703-263-6

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