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Assessing Organismal Aging in the Filamentous Fungus Podospora anserina

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Cell Senescence

Part of the book series: Methods in Molecular Biology ((MIMB,volume 965))

Abstract

Podospora anserina is an extensively studied model organism to unravel the mechanism of organismal aging. This filamentous fungus is short-lived and accessible to experimentation. Aging and lifespan are controlled by genetic and environmental traits and, in this model, have a strong mitochondrial etiology. Here, we describe methods and protocols to manipulate and study the aging process in P. anserina at different levels including biochemistry, cell biology, genetics, and physiology.

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Author information

Authors and Affiliations

  1. Faculty of Biosciences, Institute of Molecular Biosciences, Johann Wolfgang Goethe University Frankfurt, Frankfurt, Germany

    Heinz D. Osiewacz, Andrea Hamann & Sandra Zintel

  2. Frankfurt Cluster of Excellence “Macromolecular Complexes”, Frankfurt, Germany

    Heinz D. Osiewacz, Andrea Hamann & Sandra Zintel

Authors
  1. Heinz D. Osiewacz
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  2. Andrea Hamann
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  3. Sandra Zintel
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Corresponding author

Correspondence to Heinz D. Osiewacz .

Editor information

Editors and Affiliations

  1. Institut Gustave Roussy, Pavillon de Recherche 1, INSERM U848, rue C. Desmoulins 39, Villejuif, 94085, France

    Lorenzo Galluzzi

  2. Institut Gustave Roussy, Pavillon de Recherche 1, INSERM U848, rue C. Desmoulins 39, Villejuif CEDEX, 94085, France

    Ilio Vitale

  3. Institut Gustave Roussy, Pavillon de Recherche 1, INSERM U848, rue C. Desmoulins 39, Villejuif CEDEX, 94085, France

    Oliver Kepp

  4. Institut Gustave Roussy (IGR), Pavillon de Recherche 1, INSERM, U848, rue Camille-Desmoulins 39, Villejuif, 94805, France

    Guido Kroemer

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Osiewacz, H.D., Hamann, A., Zintel, S. (2013). Assessing Organismal Aging in the Filamentous Fungus Podospora anserina . In: Galluzzi, L., Vitale, I., Kepp, O., Kroemer, G. (eds) Cell Senescence. Methods in Molecular Biology, vol 965. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-239-1_29

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  • DOI: https://doi.org/10.1007/978-1-62703-239-1_29

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-238-4

  • Online ISBN: 978-1-62703-239-1

  • eBook Packages: Springer Protocols

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