Fundamentals of Microfluidics for High School Students with No Prior Knowledge of Fluid Mechanics

  • Vishal TandonEmail author
  • Walter Peck
Part of the Methods in Molecular Biology book series (MIMB, volume 949)


Three microfluidics-based laboratory exercises were developed and implemented in a high school science classroom setting. The first exercise demonstrated ways in which flows are characterized, including viscosity, turbulence, shear stress, reversibility, compressibility, and hydrodynamic resistance. Students characterized flows in poly(dimethylsiloxane) microfluidic devices in the other two exercises, where they observed the mixing characteristics of laminar flows, and conservation of volumetric flow rate for incompressible flows. In surveys, the students self-reported increased knowledge of microfluidics, and an improved attitude toward science and nanotechnology.

Key words

Microfluidics Fluid mechanics High school physics Reynolds number Hydraulic resistance Laminar flow Continuity Dynamic similarity Lab-on-a-chip Microfluidics education Teaching methods 


  1. 1.
    Freedman MP (1997) Relationship among laboratory instruction, attitude toward science, and achievement in science knowledge. J Res Sci Teach 34(4):343–357CrossRefGoogle Scholar
  2. 2.
    Anderson RD (2002) Reforming science teaching: what research says about inquiry. J Sci Teach Educ 13(1):1–12CrossRefGoogle Scholar
  3. 3. Accessed 12 Nov 2012
  4. 4.
    Stone HA, Stroock AD, Ajdari A (2004) Engineering flows in small devices: microfluidics toward a lab-on-a-chip. Annu Rev Fluid Mech 36:381–411CrossRefGoogle Scholar
  5. 5.
  6. 6.
  7. 7.
    McDonald JC, Duffy DC, Anderson JR, Chiu DT, Wu H, Schueller OJA, Whitesides GM (2000) Fabrication of microfluidic systems in poly(dimethylsiloxane). Electrophoresis 21:27–40CrossRefGoogle Scholar
  8. 8.
    Yang CWT, Ouellet E, Lagally ET (2010) Using inexpensive jell-o chips for hands-on microfluidics education. Anal Chem 82:5408–5414CrossRefGoogle Scholar
  9. 9.
    Kondapalli S, Kirby BJ (2009) Refolding of beta-galactosidase: microfluidic device for reagent metering and mixing and quantification of refolding yield. Microfluid Nanofluid 7:275–281CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media,LLC 2013

Authors and Affiliations

  1. 1.Department of Biomedical EngineeringCornell UniversityIthacaUSA
  2. 2.Whitney Point High SchoolWhitney PointUSA

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