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TRP Channels in Drug Discovery pp 89–102Cite as

TRPM2 Function and Potential as a Drug Target

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Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

Abstract

The TRPM subfamily of transient receptor potential channels includes a number of members which are involved in cell proliferation or cell survival. TRPM2, the second member to be cloned, has a key role in the response to oxidative stress. After exposure to oxidant stress, TNFα, concanavalin A, or amyloid β-peptide, ADP-ribose is produced, which binds to a NUDT9-H domain in the C terminus and is a key regulator of channel opening and calcium influx. The important roles of TRPM2 isoforms in cell proliferation and oxidant-induced cell death have been well established in divergent cell types using a broad range of techniques including overexpression, channel knockout, depletion, or inhibition, and calcium chelation. Related to its central role in oxidative stress-induced cell injury, TRPM2 has been shown to mediate a number of disease processes. TRPM2 is involved in regulation of metabolism in diabetes (insulin secretion, β-cell injury, and insulin resistance), and obesity. It has a role in inflammation, immunity, and cancer. Modulation of TRPM2 may be able to ameliorate a number of these disease processes as well as those resulting from ischemia–reperfusion injury, vascular endothelial damage, and traumatic brain injury. A review of the involvement of TRPM2 in these physiological and pathophysiological processes, and its tremendous potential as a drug target is presented below.

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Authors and Affiliations

  1. Departments of Pediatrics and Biochemistry & Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA, USA

    Barbara A. Miller

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  1. Barbara A. Miller
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Correspondence to Barbara A. Miller .

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  1. , Transfusion Services, Monmouth Medical Center, Second Avenue 300, Long Branch, 07740, New Jersey, USA

    Arpad Szallasi

  2. Medical and Health Science Center, Department of Physiology, University of Debrecen, Nagyerdei Krt. 98, Debrecen, 4032, Hungary

    Tamás Bíró

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Miller, B.A. (2012). TRPM2 Function and Potential as a Drug Target. In: Szallasi, A., Bíró, T. (eds) TRP Channels in Drug Discovery. Methods in Pharmacology and Toxicology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-077-9_5

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  • DOI: https://doi.org/10.1007/978-1-62703-077-9_5

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